Biomaterial Physical Cues as Gene Regulators for Cellular Agriculture
This review elucidates how biomaterial physical cues—ranging from matrix stiffness to remote electromagnetic fields—serve as extrinsic regulators of gene expression in cellular agriculture. By identifying central mechanotransduction pathways that bridge physical inputs to genetic remodeling, the authors propose the “Material Genome” concept: a ...
Jianuo Liu, Ye Liu
wiley +1 more source
A Structural Landscape Depiction of Dynamic Stability Centers of Local Structure in Protein Thermostability Engineering. [PDF]
Qiu X +8 more
europepmc +1 more source
ABSTRACT Background Cancer cachexia is a debilitating syndrome characterized by severe skeletal muscle wasting, which significantly impairs patient quality of life and survival. Indoleamine 2,3‐dioxygenase 1 (IDO1), a key enzyme in tryptophan (Trp) metabolism, is often upregulated in cancers, but its specific role in driving lung cancer–associated ...
Leng Han +12 more
wiley +1 more source
Genome Annotation and Catalytic Profile of <i>Rhodococcus rhodochrous</i> IEGM 107, Mono- and Diterpenoid Biotransformer. [PDF]
Plotnitskaya NA +2 more
europepmc +1 more source
PFAS properties and destruction methods: A focus on enzymatic degradation
Abstract Per‐ and polyfluoroalkyl substances (PFAS) are known as ‘forever’ chemicals and have lasting detrimental impact on the environment and living organisms. To understand PFAS molecules better, this review begins with an overview of PFAS definition, classifications and applications, and then provides a comprehensive summary and critical analysis ...
Guobin Liang, Hua Zhao
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Pan-Genomic and Phenotypic Characterisation of Petroleum Hydrocarbon Degradation by Pseudomonas Species. [PDF]
Guo X +9 more
europepmc +1 more source
Abstract BACKGROUND Sweet cherry (Prunus avium L.) is a high‐value fruit crop, but its commercial success is often limited by poor pigmentation, reduced firmness, and short shelf life. This study evaluated the effects of preharvest applications of prohexadione‐calcium (1.5 L ha−1) on fruit quality and storage performance in lowland and hilly orchards ...
Alice Varaldo +3 more
wiley +1 more source
Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics
Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang +7 more
wiley +1 more source
Comparative genomics of dominant members of the gut core microbiome of the bark beetle, Dendroctonus rhizophagus (Curculionidae: Scolytinae) reveals potential functional complementarity in the detoxification process. [PDF]
Vazquez-Ortiz K +2 more
europepmc +1 more source
Targeting EZH2 in Cancer: From Molecular Mechanisms to Clinical Translation
The abnormal overexpression or gain‐of‐function mutations of EZH2 play a significant role in cancer occurrence and progression, highlighting the importance and potential of EZH2 as a cancer biomarker. Therefore, screening for effective and safe small‐molecule inhibitors, degraders, and natural compounds targeting EZH2 through preclinical cancer models ...
Xi Zhong +4 more
wiley +1 more source

