Results 121 to 130 of about 2,475,393 (270)

Periodontal Therapy–Related Changes in Clinical Parameters, Active‐Matrix Metalloproteinase‐8 and C‐Reactive Protein in Prediabetes and Diabetes

Oral Diseases, EarlyView.
ABSTRACT Objectives This study investigated the effect of nonsurgical periodontal therapy (NSPT) on periodontal clinical parameters, active‐matrix metalloproteinase‐8 (aMMP‐8), high sensitivity C‐reactive protein (hsCRP), and glycated hemoglobin (HbA1c), and their relationships in diabetes and prediabetes patients with periodontitis.
Kehinde Adesola Umeizudike, Olayiwola Ibrahim Olaoye, Ayodele Charles Ogundana, Ismo T. Räisänen, Solomon Olusegun Nwhator, Babatunde Yusuf Alli, Patricia Omowunmi Ayanbadejo, Olufemi Adetola Fasanmade, Timo Sorsa   +8 more
wiley   +1 more source

Exploring the dipeptidyl peptidase-IV inhibitory potential of probiotic-fermented milk: An in vitro and in silico comprehensive investigation into peptides from milk of different farm animals

Journal of Dairy Science
: Bioactive peptides produced via enzymatic hydrolysis have been widely investigated for their dipeptidyl peptidase-IV (DPP-IV) inhibitory properties.
Priti Mudgil, Chee-Yuen Gan, Pei-Gee Yap, Ali Ali Redha, Reem H. Sultan Alsaadi, Khaja Mohteshamuddin, José E. Aguilar-Toalá, Abraham M. Vidal-Limon, Andrea M. Liceaga, Sajid Maqsood   +9 more
doaj   +1 more source

Sodium-glucose cotransporter 2 inhibitors combined with dipeptidyl peptidase-4 inhibitors in the management of type 2 diabetes: a review of current clinical evidence and rationale

, 2017
Sayf A Yassin,1 Vanita R Aroda2 1MedStar Union Memorial Hospital, Baltimore, 2MedStar Health Research Institute, Hyattsville, MD, USA Abstract: Type 2 diabetes mellitus (T2DM) is a progressive and multifactorial cardiometabolic disorder. Almost half of
Yassin SA, Aroda VR
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Discovery of C-(1-aryl-cyclohexyl)-methylamines as selective, orally available inhibitors of dipeptidyl peptidase IV.

, 2014
The successful launches of dipeptidyl peptidase IV (DPP IV) inhibitors as oral anti-diabetics warrant and spur the further quest for additional chemical entities in this promising class of therapeutics.
Trappe, Joerg, Ferreira, Suzie, Ostermann, Nils, Sedrani, Richard, Hassiepen, Ulrich, Sirockin, Finton, Gerhartz, Bernd, Fenton, Gary, Gessier, Francois, Sutton, Jon M., Namoto, Kenji, Beswick, Mandy, Baeschlin, Daniel, Clark, David E., Flohr, Stefanie, Duttaroy, Alokesh   +15 more
core   +1 more source

Biological definition of periodontal diseases: A historical review of host‐response diagnostics and their implications for disease classification

Periodontology 2000, EarlyView.
Abstract Background Understanding periodontal diseases through a biological lens has been a central aim in periodontal research. Visionary pioneers in the field established the foundations of our knowledge, providing invaluable insights into disease mechanisms and progression.
Nagihan Bostanci, Melissa M. Grant, Moritz Kebschull   +2 more
wiley   +1 more source

Intestinal epithelial injury and inflammation after physical work in temperate and hot environments in older men with hypertension or type 2 diabetes

Experimental Physiology, EarlyView.
Abstract We tested whether older adults with well‐controlled type 2 diabetes or hypertension, compared with age‐matched adults without chronic disease, exhibit greater intestinal damage, microbial translocation and inflammation during exertional heat stress.
Ben J. Lee, Tessa R. Flood, Sophie L. Russell, James J. McCormick, Kelli E. King, Naoto Fujii, Tatsuro Amano, Sean Notley, Glen P. Kenny   +8 more
wiley   +1 more source

Dynamic Changes in Metabolic Syndrome and Risk of Hepatocellular Carcinoma: Evidence From a Nationwide Japanese Cohort

Liver International Communications, Volume 7, Issue 4, December 2026.
ABSTRACT Aim Metabolic syndrome (MetS) is a known risk factor for hepatocellular carcinoma (HCC), but the impact of cumulative MetS burden and changes in MetS status over time remains unclear. This study aimed to assess these associations using a large‐scale Japanese health dataset.
Yutaka Yata, Naoki Kimoto, Yohei Miyashita, Takeshi Aketa, Takashi Washio, Kosuke Onoue, Masami Yabumoto, Sawako Uchida‐Kobayashi, Norifumi Kawada, Masafumi Kitakaze   +9 more
wiley   +1 more source

Structure-based discovery of dipeptidyl peptidase IV inhibitors

Structure-based discovery of dipeptidyl peptidase IV inhibitors. Diabetes afflicts approximately 151 million people worldwide, with an estimated increase to 221 million by 2010.

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Synthesis and Characterization of Constrained Peptidomimetic Dipeptidyl Peptidase IV Inhibitors:  Amino-Lactam boroAlanines

, 2007
We describe here the epimerization-free synthesis and characterization of a new class of conformationally constrained lactam aminoboronic acid inhibitors of dipeptidyl peptidase IV (DPP IV; E.C. 3.4.14.5).
Jack H. Lai (1883839), Wengen Wu (1883827), Sarah E. Poplawski (2182922), James L. Sudmeier (1883845), Yuhong Zhou (2414881), William W. Bachovchin (1883854), Lawrence J. Milo (2182926), Yuxin Liu (505575), David G. Sanford (1883824), Hlaing H. Maw (2654221), Gillian D. Henry (2303200)   +10 more
core   +1 more source

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, Volume 123, Issue 11, Page 3079-3105, November 2026.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source