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Potent Inhibitors of Dipeptidyl Peptidase iv and Their Mechanisms of Inhibition
2006Dipeptidyl peptidase IV (DP IV) is a proline specific serine protease which cleaves Xaa-Pro-dipeptides from the N-terminus of longer peptides. A series of product analogous amino acid amides containing different structure modifications like substitution of a ring atom, variation of the ring size and/or the introduction of a thioxo amide bond, phosphono
A, Stöckel-Maschek +5 more
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GLP-1 Agonists and Dipeptidyl-Peptidase IV Inhibitors
2011Novel therapeutic options for type 2 diabetes based on the action of the incretin hormone glucagon-like peptide-1 (GLP-1) were introduced in 2005. Incretin-based therapies consist of two classes: (1) the injectable GLP-1 receptor agonists solely acting on the GLP-1 receptor and (2) dipeptidyl-peptidase inhibitors (DPP-4 inhibitors) as oral medications ...
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Dipeptidyl Peptidase IV Inhibitors for the Treatment of Diabetes
Journal of Medicinal Chemistry, 2004openaire +2 more sources
Safety of dipeptidyl peptidase-4 inhibitors for treating type 2 diabetes
Expert Opinion on Drug Safety, 2015André Scheen
exaly