Dipeptidyl-peptidases: Key enzymes producing entry forms of extracellular proteins in asaccharolytic periodontopathic bacterium Porphyromonas gingivalis [PDF]
Molecular Oral Microbiology, Volume 36, Issue 2, Page 145-156, April 2021., 2020 Porphyromonas gingivalis, a pathogen of chronic periodontitis, is an asaccharolytic microorganism that solely utilizes nutritional amino acids as its energy source and cellular constituents.
Ohara, Nemoto Yuko, Nemoto, Takayuki K.
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The Caenorhabditis elegans DPF-3 and human DPP4 have tripeptidyl peptidase activity. [PDF]
FEBS LettThe dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Trivedi A, Gudipati RK.
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Dipeptidyl-peptidase I does not functionally compensate for the loss of tripeptidyl-peptidase I in the neurodegenerative disease late-infantile neuronal ceroid lipofuscinosis [PDF]
Biochemical Journal, 2008 LINCL (late-infantile neuronal ceroid lipofuscinosis) is a fatal neurodegenerative disease resulting from mutations in the gene encoding the lysosomal protease TPPI (tripeptidyl-peptidase I). TPPI is expressed ubiquitously throughout the body but disease appears restricted to the brain. One explanation for the absence of peripheral pathology is that in
Kwi-Hye, Kim +3 more
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Cellular locations of proteinases and association with vesicles in
European Journal of Medical Research, 2010 We found that locations of arginine-specific gingipain (RGP) in the cellular fractions in the crude extract, envelope, vesicles, and culture supernatants were 48%, 16%, 17%, and 31%, respectively, and the corresponding values of lysine-specific gingipain
Oishi S +7 more
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Abstract In recent decades, microbiome research has progressed profoundly from exploring microbial diversity to uncovering host-microbial-isozymes (HMI). The understanding of the implications for human health of one such HMI, microbially derived dipeptidyl peptidases, remains limited, despite their structural and functional similarities
Mashael Aljumaah +7 more
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Identification and characterization of burkholderia pseudomallei K96243 serine and metallopeptidase
, 2014 Burkholderia pseudomallei K96243, the causative agent of melioidosis, is reported to produce various extracellular products, including proteases. The role of these proteases in the melioidosis, however, remains obscure.
Azizan, Muhammad Talhah +1 more
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Influence of adrenomedullin on the enzymatic activity of dipeptidyl peptidase 3 <i>in vitro</i>. [PDF]
J Enzyme Inhib Med ChemNissen R +6 more
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Coordinated regional association of cathepsins and dipeptidyl peptidases with N-truncated Abeta42, Abeta40, and tau in Alzheimer's brain. [PDF]
Acta Neuropathol CommunShinohara M +7 more
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A DPP inhibitor suppresses periodontitis via antibacterial effect targeting Porphyromonas gingivalis. [PDF]
Sci RepAoki-Nonaka Y +12 more
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Contribution of UbrA, a ubiquitin ligase essential for Arg/N-degron pathway, to peptidase gene expression in <i>Aspergillus oryzae</i>. [PDF]
Appl Environ MicrobiolMuromachi W +4 more
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