Results 1 to 10 of about 5,637 (129)

The Caenorhabditis elegans DPF-3 and human DPP4 have tripeptidyl peptidase activity. [PDF]

FEBS Lett
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Trivedi A, Gudipati RK.
europepmc   +2 more sources

Dipeptidyl-peptidase I does not functionally compensate for the loss of tripeptidyl-peptidase I in the neurodegenerative disease late-infantile neuronal ceroid lipofuscinosis [PDF]

Biochemical Journal, 2008
LINCL (late-infantile neuronal ceroid lipofuscinosis) is a fatal neurodegenerative disease resulting from mutations in the gene encoding the lysosomal protease TPPI (tripeptidyl-peptidase I). TPPI is expressed ubiquitously throughout the body but disease appears restricted to the brain. One explanation for the absence of peripheral pathology is that in
Kwi-Hye, Kim, Christine T, Pham, David E, Sleat, Peter, Lobel   +3 more
openaire   +2 more sources

Cellular locations of proteinases and association with vesicles in porphyromonas gingivalis

European Journal of Medical Research, 2010
We found that locations of arginine-specific gingipain (RGP) in the cellular fractions in the crude extract, envelope, vesicles, and culture supernatants were 48%, 16%, 17%, and 31%, respectively, and the corresponding values of lysine-specific gingipain
Oishi S, Miyashita M, Kiso A, Kikuchi Y, Ueda O, Hirai K, Shibata Y, Fujimura S   +7 more
doaj   +1 more source

Gut Microbial Dipeptidyl Peptidase-4 and Associated Prolyl Tripeptidyl Peptidases: A Novel Classification and Response to Inhibitors

Abstract In recent decades, microbiome research has progressed profoundly from exploring microbial diversity to uncovering host-microbial-isozymes (HMI). The understanding of the implications for human health of one such HMI, microbially derived dipeptidyl peptidases, remains limited, despite their structural and functional similarities
Mashael Aljumaah, Israa Isawi, Jeff Roach, Yunan Hu, Suzanne Dagher, Jose Bruno-Barcena, Rufaida Al-Zoubi, M. Andrea Azcarate-Peril   +7 more
openaire   +1 more source

Coordinated regional association of cathepsins and dipeptidyl peptidases with N-truncated Abeta42, Abeta40, and tau in Alzheimer's brain. [PDF]

Acta Neuropathol Commun
Shinohara M, Gheni G, Kawai K, Morishima M, Murayama S, Saito Y, Bu G, Sato N.   +7 more
europepmc   +1 more source

Contribution of UbrA, a ubiquitin ligase essential for Arg/N-degron pathway, to peptidase gene expression in <i>Aspergillus oryzae</i>. [PDF]

Appl Environ Microbiol
Muromachi W, Ohba M, Kawarasaki Y, Yamagata Y, Tanaka M.   +4 more
europepmc   +1 more source

Circulating dipeptidyl peptidase 3 and outcomes in acute heart failure: an analysis of the STRONG-HF and CORTAHF studies. [PDF]

ESC Heart Fail
Bruno J, Edwards C, Takaji K, Azibani F, Davison B, Cotter G, Santos K, Hartmann O, Ambrosy AP, Mebazaa A, Picod A.   +10 more
europepmc   +1 more source

Microbial dipeptidyl peptidases of the S9B family as host-microbe isozymes. [PDF]

Sci Adv
Aljumaah MR, Roach J, Hu Y, Gunstad J, Azcarate-Peril MA.   +4 more
europepmc   +1 more source

Prognosis of critically ill patients with severe acute kidney injury and high circulating dipeptidyl peptidase 3: a post hoc analysis of the AKIKI 2 trial. [PDF]

Crit Care
Picod A, Boussier J, Tubiana S, Louis G, Lefevre LM, Titeca-Beauport D, Combe B, Besset S, Badie J, Chevrel G, Chudeau N, Barbar S, Vinsonneau C, Forel JM, Thevenin D, Lacave G, Nseir S, Oziel J, Mayaux J, Klouche K, Reignier J, Ricard JD, Quenot JP, Mebazaa A, Azibani F, Dreyfuss D, Gaudry S, Chaïbi K.   +27 more
europepmc   +1 more source

Targeting high circulating dipeptidyl peptidase 3 in circulatory failure. [PDF]

Crit Care
Picod A, Azibani F, Harjola VP, Karakas M, Kimmoun A, Levy B, Pickkers P, Thiele H, Zeymer U, Santos K, Mebazaa A.   +10 more
europepmc   +1 more source