Results 231 to 240 of about 15,704,457 (348)

Faculty Opinions recommendation of Direct use of 15N relaxation rates as experimental restraints on molecular shape and orientation for docking of protein-protein complexes.

, 2010
David Cowburn
openalex   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Endoscopic transnasal approach to pterygopalatine fossa and infratemporal fossa: case series utilizing endoscopic modified medial maxillectomy (EMMM)/direct approach to the anterior and lateral part of the maxillary sinus (DALMA). [PDF]

Acta Neurochir (Wien)
Umekawa M, Hasegawa H, Shinya Y, Shin M, Kondo K, Miyawaki S, Saito N.   +6 more
europepmc   +1 more source

AM radio navigation using direct conversion phase measurements.

, 1997
Anh Dinh
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Oxygen-releasing seed coating enhances yield and resource use efficiency in direct-seeded rice. [PDF]

Front Plant Sci
Shi Y, Yin H, Zhu Y, Liu R, Chen Q, Xie H, Liu B, Cheng Q, Shu C, Liu N, Ma J, Sun Y, Li N, Yang Z.   +13 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Portal Vein Thrombectomy in Liver Transplantation for Patients With Calcified Portal Vein Thrombosis: An Extensive Case Series. [PDF]

Transplant Direct
Altshuler PJ, Roll GR, Chu SN, Zheng AC, Record HL, Hasan H, Freise CE, Yamaguchi S, Roberts JP, Syed SM.   +9 more
europepmc   +1 more source

Hemispheric Diferences In The Processing Of Visual Consequences Of Active Vs. Passive Movements: A Transcranial Direct Current Stimulation Study

, 2017
Benjamin Straube, Rasmus Schülke, Knut Drewing, Tilo Kircher, Bianca M. van Kemenade   +4 more
openalex   +1 more source

DIRECT OESOPHAGOSCOPY [PDF]

BMJ, 1910
openaire   +2 more sources