Direct AMPK Activation Corrects NASH in Rodents Through Metabolic Effects and Direct Action on Inflammation and Fibrogenesis. [PDF]
Hepatol Commun, 2022 No approved therapies are available for nonalcoholic steatohepatitis (NASH). Adenosine monophosphate–activated protein kinase (AMPK) is a central regulator of cell metabolism; its activation has been suggested as a therapeutic approach to NASH.
Gluais-Dagorn P +11 more
europepmc +2 more sources
Scaling parameter of the lethal effect of mammalian cells based on radiation-induced OH radicals: effectiveness of direct action in radiation therapy. [PDF]
J Radiat Res, 2021 We have been studying the effectiveness of direct action, which induces clustered DNA damage leading to cell killing, relative to indirect action. Here a new criterion Direct Ation-Based Biological Effectiveness (DABBLE) is proposed to understand the ...
Kusumoto T +6 more
europepmc +2 more sources
Luteinizing hormone: Evidence for direct action in the CNS. [PDF]
Horm Behav, 2015 Hormonal dysfunction due to aging, especially during menopause, plays a substantial role in cognitive decline as well as the progression and development of neurodegenerative diseases. The hypothalamic-pituitary-gonadal (HPG) axis has long been implicated
Blair JA +3 more
europepmc +2 more sources
The cognition-enhancing effects of psychostimulants involve direct action in the prefrontal cortex. [PDF]
Biol Psychiatry, 2015 Psychostimulants are highly effective in the treatment of attention deficit hyperactivity disorder (ADHD). The clinical efficacy of these drugs is strongly linked to their ability to improve cognition dependent on the prefrontal cortex (PFC) and extended
Spencer RC, Devilbiss DM, Berridge CW.
europepmc +2 more sources
Direct action of FSH on testicular stem cells [PDF]
Stem Cell Research & Therapy, 2019 Recently published article by Pieri’s group suggested that follicle-stimulating hormone (FSH) activates canine testicular spermatogonial stem cells (SSCs) and results in increased expression of pluripotent markers and formation of germ cell clumps ...
Hiren Patel, Deepa Bhartiya
doaj +2 more sources
Sildenafil increases serum testosterone levels by a direct action on the testes. [PDF]
Andrology, 2013 Phosphodiesterase‐5‐inhibitors, such as sildenafil, increase intracavernosal cyclic guanosine monophosphate levels, which results in corporal smooth muscle relaxation and penile erection.
Spitzer M +5 more
europepmc +2 more sources
Rapid direct action of estradiol in GnRH neurons: findings and implications. [PDF]
Front Endocrinol (Lausanne), 2011 Estradiol plays a pivotal role in the control of gonadotropin-releasing hormone (GnRH) neuronal function and female reproduction. While positive and negative feedback actions of estradiol that enhance and suppress release of GnRH and LH are primarily ...
Kenealy BP, Terasawa E.
europepmc +2 more sources
Autonomous Health Movements: Criminalization, De-Medicalization, and Community-Based Direct Action [PDF]
Health and Human Rights, 2020 This paper proposes the concept of autonomous health movements, drawing on an analysis of harm reduction in the United States and self-managed abortion globally.
Naomi Braine
doaj +1 more source
Direct action of endothelin-1 on podocytes promotes diabetic glomerulosclerosis. [PDF]
J Am Soc Nephrol, 2014 Lenoir O +10 more
europepmc +2 more sources