Results 71 to 80 of about 4,558,337 (307)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

THE STANDARD SINGLE COST METHOD AND THE EFFICIENCY OF INDUSTRIAL COMPANIES’ MANAGEMENT [PDF]

This article briefly describes the premises for the application of the standard direct cost calculation method in industry, the standard single cost calculation method, the stages of standard cost calculation per product and the calculation methods of ...
Claudiu C. CONSTANTINESCU
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The Direct Cost of Rheumatoid Arthritis

Value in Health, 2000
This analysis estimated the direct cost of rheumatoid arthritis (RA) from a societal perspective.Primary and secondary data sets were used to determine the rate of medical resource utilization. National average Medicare or Medicaid reimbursement rates were used to value direct costs (in 1994 dollars).Persons with RA have, on average, dollar 1702 in ...
Ward, Marcia M., Javitz, Harold S., Yelin, Edward H.   +2 more
openaire   +2 more sources

KAJIAN PENGGUNAAN ANTIBIOTIK PADA PASIEN DIARE AKUT DI BANGSAL RAWAT INAP ANAK

Jurnal Manajemen dan Pelayanan Farmasi, 2017
Pemberian terapi antibiotik untuk pasien diare akut anak yang kurang tepat merupakan salah satu tantangan dalam bidang kesehatan di berbagai negara, termasuk Indonesia.
Kristina Eni Trisnowati, Sylvi Irawati, Eko Setiawan   +2 more
doaj   +1 more source

Study of Advanced Propulsion Systems for Small Transport Aircraft Technology (STAT) Program [PDF]

Definitions of takeoff gross weight, performance, and direct operating cost for both a 30 and 50 passenger airplane were established. The results indicate that a potential direct operating cost benefit, resulting from advanced technologies, of ...
Baerst, C. F., Heldenbrand, R. W., Rowse, J. H.   +2 more
core   +1 more source

Investigations on the performances of the electrical generator of a rim-driven marine current turbine” [PDF]

, 2014
In this paper, the electrical generator of a rim-driven horizontal-axis current turbine is modeled in detail. Its main characteristics and performances are evaluated (efficiency, mass, cost, etc).
CHARPENTIER, Jean-Frederic, CLENET, Stéphane, DROUEN, Laurent, SEMAIL, Eric   +3 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Preliminary estimates of operating costs for lighter than air transports [PDF]

, 1975
A preliminary set of operating cost relationships are presented for airship transports. The starting point for the development of the relationships is the direct operating cost formulae and the indirect operating cost categories commonly used for ...
Ardema, M. D., Smith, C. L.
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source