Results 81 to 90 of about 2,570,203 (288)

Breathing dissipative solitons in optical microresonators

, 2016
Dissipative solitons are self-localized structures resulting from a double balance between dispersion and nonlinearity as well as dissipation and a driving force.
Gorodetsky, Michael, Guo, Hairun, Karpov, Maxim, Kippenberg, Tobias, Lucas, Erwan   +4 more
core   +2 more sources

Systematic study of constitutive cyclo-oxygenase-2 expression: role of NFκB and NFAT transcriptional pathways [PDF]

, 2015
Cyclooxygenase-2 (COX-2) is an inducible enzyme that drives inflammation and is the therapeutic target for widely used nonsteroidal antiinflammatory drugs (NSAIDs).
Ahmetaj-Shala, B, Berglund, LM, Chan, MV, Garcia-Vaz, E, Gomez, MF, Herschman, HR, Jiao, J, Kirkby, NS, Mitchell, JA, Verdu, EF, Wallace, JL, Zaiss, AK   +11 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Bridging prediction and decision: Advances and challenges in data-driven optimization

Nexus
Data-driven approaches have revolutionized traditional optimization methods by integrating prediction with decision-making. This review examines the theoretical foundations, strengths, recent advancements, and limitations of three key methods—sequential ...
Yanzhi Wang, Jianxiao Wang, Haoran Zhang, Jie Song   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The Need for Sensemaking in Networked Privacy and Algorithmic Responsibility [PDF]

, 2018
This paper proposes that two significant and emerging problems facing our connected, data-driven society may be more effectively solved by being framed as sensemaking challenges.
Binns, R, Seymour, W, Shadbolt, N, Van Kleek, M, Veale, M   +4 more
core  

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Administration of direct-fed Bacillus cultures and refined functional carbohydrates to broiler chickens improves growth performance and promotes positive shifts in gastrointestinal microbiota

Journal of Applied Poultry Research, 2020
Summary: Due to regulation and consumer-driven decreases in the use of antibiotics, there is a critical need for the development of alternatives to antibiotic growth promoters (AGP) for use in poultry production.
L.K. Froebel, S. Jalukar, T.A. Lavergne, C.D. Coufal, T. Duong   +4 more
doaj   +1 more source

Economic aspects of multi-source demand-side consumption optimization in the smart home concept [PDF]

, 2015
Current energy consumption trends lead to rapidly growing consumption of local renewable energy sources. Such installations bring new requirements on energy consumption profiles.
Horák, Aleš, Mišák, Stanislav, Prokop, Lukáš, Prýmek, Miroslav   +3 more
core   +1 more source