FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Detection, Speech Recognition, Loudness, and Preference Outcomes With a Direct Drive Hearing Aid: Effects of Bandwidth. [PDF]
Trends Hear, 2021 Folkeard P +7 more
europepmc +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
One-dimensional hydrodynamic simulations of low convergence ratio direct-drive inertial confinement fusion implosions. [PDF]
Philos Trans A Math Phys Eng Sci, 2021 Paddock RW +11 more
europepmc +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Development and Prospect of Axial Field Permanent Magnet Machine
Kongzhi Yu Xinxi Jishu, 2014 Because of shorter axial dimension and higher specific torque, axial field permanent magnet (AFPM) machine is very suitable for the applications that axial space is limited and low speed and direct drive is required.
KE Siqin
doaj
Diagnosing the fast-heating process of the double-cone ignition scheme with X-ray spectroscopy
High Power Laser Science and EngineeringIn the double-cone ignition scheme of inertial confinement fusion, the head-on collision of two compressed fuel jets from the cone-tips forms an isochoric plasma, which is then heated suddenly by a MeV relativistic electron beam produced by ultra-intense
Yu Dai +9 more
doaj +1 more source
AdjustSense: Adaptive 3D Sensing System with Adjustable Spatio-Temporal Resolution and Measurement Range Using High-Speed Omnidirectional Camera and Direct Drive Motor. [PDF]
Sensors (Basel), 2021 Ikura M +4 more
europepmc +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source