Results 181 to 190 of about 2,076,692 (292)

Direct Imaging of Chirality Transfer Induced by Glycosidic Bond Stereochemistry in Carbohydrate Self-Assemblies. [PDF]

J Am Chem Soc
Cai S, Jestilä JS, Liljeroth P, Foster AS.   +3 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Direct Imaging of Radiation-Sensitive Organic Polymer-Based Nanocrystals at Sub-Ångström Resolution. [PDF]

Nanomaterials (Basel)
Carlino E, Taurino A, Hasa D, Bučar DK, Polentarutti M, Chinchilla LE, Calvino Gamez JJ.   +6 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Direct Imaging of Atomic Rattling Motion in a Clathrate Compound. [PDF]

Small Sci
Tabata K, Seki T, Findlay SD, Ishikawa R, Tamura R, Ikuhara Y, Shibata N.   +6 more
europepmc   +1 more source

Superresolved polarization-enhanced second-harmonic generation for direct imaging of nanoscale changes in collagen architecture. [PDF]

Optica, 2021
Johnson PB, Johnson PB, Karvounis A, Singh HJ, Brereton CJ, Bourdakos KN, Lunn K, Roberts JJW, Davies DE, Muskens OL, Jones MG, Mahajan S.   +11 more
europepmc   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Atomic-level direct imaging for Cu(I) multiple occupations and migration in 2D ferroelectric CuInP₂S₆. [PDF]

Nat Commun
Guo C, Zhu J, Liang X, Wen C, Xie J, Gu C, Hu W.   +6 more
europepmc   +1 more source

Direct Imaging of Correlated Defect Nanodomains in a Metal-Organic Framework. [PDF]

J Am Chem Soc, 2020
Johnstone DN, Firth FCN, Grey CP, Midgley PA, Cliffe MJ, Collins SM.   +5 more
europepmc   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source