Results 101 to 110 of about 3,477,747 (293)

Direct immunofluorescence and histopathology in chronic discoid lupus erythematosus

, 2016
Background Lesions of chronic discoid lupus erythematosus (DLE) are characterized by sharply demarcated, scaly, infiltrated and later atrophic red discoid plaques.
Sabrina Suhail Pal, Shahzana Naqqash, Faria Asad   +2 more
core   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Resist the WTO roadshow : sponsored by the Direct Action Network Against Corporate Globalization and Global Exchange [verso]

, 1999
Alternate title: Resist the World Trade Organization roadshow. Also sent out as document 12 of 19 in a Direct Action Network (DAN) organizing packet; these documents are contained in a 9 X 12 inch envelope stating approximately 50-100 organizing packets
Direct Action Network (DAN)
core  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

NHS Direct

, 2002
NHS Direct operates a 24-hour nurse advice and health information service, providing confidential information on: What to do if you or your family are feeling ill; Particular health conditions; Local healthcare services, such as doctors, dentists or late
NHS Direct
core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Demographic characteristics and disease severity associated with IgA/IgG deposition patterns in autoimmune bullous diseases: a cohort study based on a registry database

Frontiers in Immunology
BackgroundDirect immunofluorescence (DIF) microscopy is the gold standard for diagnosing autoimmune bullous diseases (AIBDs), but the clinical significance of IgA and IgG co-deposition was unclear.ObjectiveInvestigate the demographic differences and ...
Jishu Li, Jishu Li, Xun Feng, Xun Feng, Mi Wang, Hongjie Liu, Mei Yang, Jiyun Pang, Min Zou, Yue Xiao, Xiwen Zhang, Hongxiang Hu, Yuxi Zhou, Yazan Moufaq Alqusseireen, Wei Yan, Xingli Zhou, Wei Li   +16 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Direct Immunofluorescence study of Immunobullous Disorders [PDF]

, 2020
BACKGROUND: Autoimmune bullous disorders are rare dermatological disorders, ranging in incidence from 0.5 – 3.2 cases/1,00,000/year. Due to their rarity and polymorphic presentation, these disorders pose a diagnostic challenge, hence it is essential to ...
Ajith Kumar, L B
core  

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source