Results 261 to 270 of about 8,273,193 (339)

Direct PCR-Based VNTR Analysis of TPO Intron 10 for Rapid Detection of Maternal Cell Contamination in Prenatal Diagnosis. [PDF]

Clin Transl Sci
Wichian P, Pattrakorn A, Fucharoen S, Srivorakun H, Prommetta S, Yamsri S.   +5 more
europepmc   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Ghost peaks mitigation with target-contaminated reference signal in passive bistatic radar. [PDF]

Sci Rep
Zhang Y, Ge L, Wu Y.
europepmc   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Direct, indirect and intangible costs incurred by leptospirosis patients: the magnitude, aspects and methods of assessing the costs - a systematic review and meta-analysis protocol. [PDF]

BMJ Open
Jayasinghe MS, Warnasekara J, Gunarathna SP, Wickramasinghe ND, Agampodi S.   +4 more
europepmc   +1 more source

Manufacturability Assessment of Design Decisions for Reducing Material Diversity in Single-Piece and Small-Batch Production. [PDF]

Materials (Basel)
Więcek D, Więcek D, Kuric I.
europepmc   +1 more source

3D intraoral scanner as an auxiliary tool for the diagnosis of dental hard-tissue conditions. [PDF]

Clin Oral Investig
Valdivia Tapia AC, Lara JS, Martinez-Mier EA, Denucci GC, Lippert F, Eckert GJ, Hara AT.   +6 more
europepmc   +1 more source

Evaluation of direct microbial identification by MALDI-TOF MS and antimicrobial susceptibility testing for early diagnosis of blood stream infections. [PDF]

BMC Microbiol
Tejan N, Fatima N, Yaduvanshi N, Singh R, Pathak A, Hasan I, Patel SS, Sahu C.   +7 more
europepmc   +1 more source

Dyslipidemia Assessed in Pediatric Patients: Validation of LDL-C Assessed by Friedewald Formula, Direct Assessment, and Sampson-NIH Formula. [PDF]

Diagnostics (Basel)
Wawer J, Chojęta A, Swadźba J, Janiszewska M, Chojęta M, Wawer GA, Grywalska E, Milaniuk A.   +7 more
europepmc   +1 more source