Results 131 to 140 of about 504,051 (284)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Direct medical cost analysis of breast cancer treatment at Jimma University Medical Center: a provider perspective

Cost Effectiveness and Resource Allocation
Introduction Breast cancer is an evolving non-communicable disease and a global disease burden, which accounts for a momentous portion of worldwide mortality and morbidity with significant economic impacts.
Gebeyehu Jeldu Edessa, Kidist Adamu Kare, Aleka Jeldu Edessa, Dawit Wolde Daka   +3 more
doaj   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Total cost (direct medical costs and the cost to the patient and caregiver) of DF by year and care setting.

, 2018
Total cost (direct medical costs and the cost to the patient and caregiver) of DF by year and care setting.
Luis Durán-Arenas (2922009), Adrian Ramírez-Chávez (2922000), Sendy Isarel Hernández-Gaytán (6087140), Guillermo Salinas-Escudero (2736256), Adriana Zubieta-Zavala (2922003), Juan Guillermo López Yescas (2922012), Malaquias López-Cervantes (2922015), José Ramos Castañeda (6087137)   +7 more
core   +1 more source

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi, Giorgio Ricciardiello Mejia, Andre Metzger, Kang Hyun Ryu, Salonee Marwaha, Eva Grzegorczyk, Li Zhou, Eliana Jacobs, Boris Gilyadov, Claudia Kunney, Liqhwa Ncube, Ankit Parekh, Emmanuel Mignot, Fanny M. Elahi, Joseph Winer, Kathleen Poston, Andreas Brink‐Kjaer, Emmanuel H. During   +17 more
wiley   +1 more source

Non-medical direct and indirect costs related to primary open-angle glaucoma in Brazil

Revista Brasileira de Oftalmologia, 2019
Sirley Maria de Freitas, Ricardo Augusto Paletta Guedes, Vanessa Maria Paletta Guedes, Laura Assis de Castro Paletta, Daniela Marcelo Gravina, Alfredo Chauobah   +5 more
openaire   +1 more source

A Qualitative Analysis of Patient Perspectives and Preferences in Lupus Management to Guide Lupus Guidelines Development

Arthritis Care &Research, EarlyView.
Objective A patient‐centered approach for chronic disease management, including systemic lupus erythematosus (SLE), aligns treatment with patients’ values and preferences, leading to improved outcomes. This paper summarizes how patient experiences, perspectives, and priorities informed the American College of Rheumatology (ACR) 2024 Lupus Nephritis (LN)
Shivani Garg, Izzy Hartel, Lisa R. Sammaritano, Anca Askanase, Bonnie L. Bermas, Maria Dall'Era, Alí Duarte‐García, Victoria P. Werth, Brad Rovin, Reem A. Mustafa, Amy S. Turner, Bené Williams, Brian L. Ung, Hiya Bhavsar, Monique C. Gore‐Massy, Nahirannette Pulido, Natacha Guerrero, Natalie M. Smith, Wambui Machua, Linda T. Hiraki, Mary Beth Son   +20 more
wiley   +1 more source

Assessing the Length of Hospital Stay and Economic Outlay for Therapy in Chronic Kidney Disease Patients in a Tertiary Care Hospital

Journal of Pharmacoeconomics and Pharmaceutical Management
Background: To assess the LOS and costs for hospitalized CKD patients, to compare the pharmacoeconomic-related direct medical and non-medical costs among pre-dialysis and dialysis patients, and to determine the impact of CKD with other comorbidities on ...
Risana V U, Kiron S S, Dhanin Puthiyottil, Sauparnika Soman, Muhammed Shaliqe K   +4 more
doaj  

Raw cost and meta-analysis of direct medical costs.^†

, 2016
Raw cost and meta-analysis of direct medical costs.†
Lan Gao (61471), Shu-Chuen Li (2185669), Fei-Li Zhao (2185666), Hao Hu (111737)   +3 more
core   +1 more source

Validation of the Pediatric Arthritis Ultrasound Scoring System for the Elbow, Wrist, and Finger Joints in Children With Juvenile Idiopathic Arthritis

Arthritis Care &Research, EarlyView.
Objective We aimed to validate the Pediatric Arthritis Ultrasound Scoring System (PAUSS) for upper extremity joints in children with juvenile idiopathic arthritis (JIA). Methods Children with JIA were evaluated for elbow, wrist, or finger arthritis by clinical examination (CE) and musculoskeletal ultrasound (MSUS) with images scored according to the ...
Patricia Vega‐Fernandez, Pinar Ozge Avar‐Aydin, Kelly Rogers, Daniel J. Lovell, Jennifer Huggins, Alexei Grom, Hermine I. Brunner, Grant S. Schulert, Sheila T. Angeles‐Han, Mekibib Altaye, Amy Cassedy, Arthur B. Meyers, Tracy V. Ting   +12 more
wiley   +1 more source