Results 111 to 120 of about 1,892,200 (345)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Instanton filtering for the stochastic Burgers equation

, 2012
We address the question whether one can identify instantons in direct numerical simulations of the stochastically driven Burgers equation. For this purpose, we first solve the instanton equations using the Chernykh-Stepanov method [Phys. Rev.
, Cole J, Phythian R, Rainer Grauer, Tobias Grafke, Tobias Schäfer   +5 more
core   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Dispersive shock waves in the Kadomtsev-Petviashvili and Two Dimensional Benjamin-Ono equations

, 2015
Dispersive shock waves (DSWs) in the Kadomtsev-Petviashvili (KP) equation and two dimensional Benjamin-Ono (2DBO) equation are considered using parabolic front initial data.
Ablowitz, Mark J., Demirci, Ali, Ma, Yi-Ping   +2 more
core   +1 more source

Global gyrokinetic simulations of ITG turbulence in the configuration space of the Wendelstein 7-X stellarator

, 2020
We study the effect of turbulent transport in different magnetic configurations of the Weldenstein 7-X stellarator. In particular, we performed direct numerical simulations with the global gyrokinetic code GENE-3D, modeling the behavior of Ion ...
Di Siena, A., Hindenlang, F., Jenko, F., Maurer, M., Merlo, G., Navarro, A. Bañón, Plunk, G. G., von Stechow, A., Wilms, F., Xanthopoulos, P.   +9 more
core   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Lifetimes of Rogue Wave Events in Direct Numerical Simulations of Deep-Water Irregular Sea Waves

Fluids, 2019
The issue of rogue wave lifetimes is addressed in this study, which helps to detail the general picture of this dangerous oceanic phenomenon. The direct numerical simulations of irregular wave ensembles are performed to obtain the complete accurate data ...
Anna Kokorina, Alexey Slunyaev
doaj   +1 more source

Light propagation beyond the mean-field theory of standard optics

, 2016
With ready access to massive computer clusters we may now study light propagation in a dense cold atomic gas by means of basically exact numerical simulations.
Javanainen, Juha, Ruostekoski, Janne
core   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Direct Numerical Simulation of Turbulent Flows Laden with Droplets or Bubbles

Annual Review of Fluid Mechanics, 2019
This review focuses on direct numerical simulations (DNS) of turbulent flows laden with droplets or bubbles. DNS of these flows are more challenging than those of flows laden with solid particles due to the surface deformation in the former.
S. Elghobashi
semanticscholar   +1 more source