Results 71 to 80 of about 1,892,200 (345)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Effect of airflow rate on CO2 concentration in downflow indoor ventilation

Indoor Environments
We perform direct numerical simulations to study the effect of increasing airflow rate on CO2 concentration in downflow and displacement ventilation in a room with one occupant.
Guru Sreevanshu Yerragolam, Christopher J. Howland, Rui Yang, Richard J.A.M. Stevens, Roberto Verzicco, Detlef Lohse   +5 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Flamelet Characteristics of Gaseous and Spray Lifted Flames on Two-Dimensional Direct Numerical Simulations

Journal of Fluid Science and Technology, 2008
The detailed behaviors of gaseous and spray lifted flames are studied by two- dimensional direct numerical simulations (DNS), and the characteristics of the flamelets are investigated in terms of two key variables for flamelet modeling, namely mixture ...
Yuya BABA, Ryoichi KUROSE
doaj   +1 more source

A Direct Numerical Simulation Assessment of Turbulent Burning Velocity Parametrizations for Non-Unity Lewis Numbers

Energies, 2023
The predictions of turbulent burning velocity parameterizations for non-unity Lewis number flames have been assessed based on a single-step chemistry Direct Numerical Simulation (DNS) database of premixed Bunsen flames for different values of ...
Vishnu Mohan, Marco Herbert, Markus Klein, Nilanjan Chakraborty   +3 more
doaj   +1 more source

Turbulent front speed in the Fisher equation: dependence on Damkohler number

, 2010
Direct numerical simulations and mean-field theory are used to model reactive front propagation in a turbulent medium. In the mean-field approach, memory effects of turbulent diffusion are taken into account to estimate the front speed in cases when the ...
Babkovskaia, N., Brandenburg, A., Haugen, N. E. L.   +2 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Entrainment and mixing at the interface of shallow cumulus clouds: Results from a combination of observations and simulations

Meteorologische Zeitschrift, 2014
This study combines observations, large-eddy simulations (LES), and direct numerical simulations (DNS) in order to analyze entrainment and mixing in shallow cumulus clouds at all relevant spatial scales and, additionally, to verify the results by the ...
Fabian Hoffmann, Holger Siebert, Jörg Schumacher, Theres Riechelmann, Jeannine Katzwinkel, Bipin Kumar, Paul Götzfried, Siegfried Raasch   +7 more
doaj   +1 more source

Direct numerical simulation of axisymmetric turbulence [PDF]

Physical Review Fluids, 2017
The dynamics of decaying strictly axisymmetric, incompressible turbulence is investigated using direct numerical simulations. It is found that the angular momentum is a robust invariant of the system. It is further shown that long-lived coherent structures are generated by the flow, associated with stationary solutions of the Euler equations.
Qu, Bo, Bos, Wouter J.T., Naso, Aurore
openaire   +1 more source