Results 81 to 90 of about 1,892,200 (345)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Verifications of the high-resolution numerical model and polarization relations of atmospheric acoustic-gravity waves [PDF]

Geoscientific Model Development, 2015
Comparisons of amplitudes of wave variations of atmospheric characteristics obtained using direct numerical simulation models with polarization relations given by conventional theories of linear acoustic-gravity waves (AGWs) could be helpful for testing ...
N. M. Gavrilov, S. P. Kshevetskii, A. V. Koval   +2 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Scaling of Second-Order Structure Functions in Turbulent Premixed Flames in the Flamelet Combustion Regime

Fluids, 2020
The second-order velocity structure function statistics have been analysed using a DNS database of statistically planar turbulent premixed flames subjected to unburned gas forcing.
Peter Brearley, Umair Ahmed, Nilanjan Chakraborty, Markus Klein   +3 more
doaj   +1 more source

Philofluid turbulent flow database [PDF]

, 2012
A set of velocity and passive scalar fields and their statistics coming from direct numerical simulations and large-eddy simulations. The database includes: shearless mixings in two a three dimensions, turbulent channel flow, cavity flow.
Bailey, P.R., Ducasse, L., Iovieno, Michele, Tordella, Daniela   +3 more
core  

Comparison of spectral slopes of magnetohydrodynamic and hydrodynamic turbulence and measurements of alignment effects

, 2009
We performed a series of high-resolution (up to 1024^3) direct numerical simulations of hydro and MHD strong turbulence. We found that for simulations with normal viscosity the slopes for spectra of MHD are similar, although slightly more shallower than ...
A. Beresnyak, A. Lazarian, Beresnyak, Beresnyak, Beresnyak, Beresnyak, Biskamp, Biskamp, Boldyrev, Cho, Cho, Cho, Crovisier, Frisch, Galtier, Haugen, Iroshnikov, Kolmogorov, Kowal, Kritsuk, Lazarian, Lazarian, Lithwick, Lithwick, Maron, Monin, Narayan, Priest, Stone, Velikhov, Yan, Zweibel   +31 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Direct Numerical Simulations of Oxygen-flame-driven Deflagration-to-detonation Transition in Type Ia Supernovae

The Astrophysical Journal
We present direct numerical simulations demonstrating deflagration-to-detonation transition (DDT) driven by oxygen flames in Type Ia supernova progenitors.
Xiaoyu Zhang, Lile Wang, Yang Gao, Yao Zhou   +3 more
doaj   +1 more source

Direct Numerical Simulations of the Kraichnan Model: Scaling Exponents and Fusion Rules

, 1997
We present results from direct numerical simulations of the Kraichnan model for passive scalar advection by a rapidly-varying random scaling velocity field for intermediate values of the velocity scaling exponent.
Fairhall, Adrienne L., Galanti, Barak, L'vov, Victor S., Procaccia, Itamar   +3 more
core   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source