Results 211 to 220 of about 1,512,078 (302)

Direct observation of cholesterol monohydrate crystallization. [PDF]

Proc Natl Acad Sci U S A
Chakraborty D, Ma W, Wang X, Chu Z, Yang T, Warzecha M, Vekilov PG, Rimer JD.   +7 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Direct observation of V-trimers in the crystal structure of LiVO₂. [PDF]

Commun Chem
Yun S, Chang CF, Chen SH, Kuo CY, Tjeng LH, Komarek AC.   +5 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Direct Observation of the Exciton-Polaron in Single CsPbBr₃ Quantum Dots. [PDF]

ACS Nano
Shen Z, Samoli M, Erdem O, Bielecki J, Samanta AK, E J, Estillore AD, Kim C, Kim Y, Koliyadu J, Letrun R, Locardi F, Lübke J, Mall A, Melo DVM, Mills G, Rafie-Zinedine S, Round A, Sato T, de Wijn R, Wollweber T, Worbs L, Zhuang Y, Mancuso AP, Bean R, Chapman HN, Küpper J, Infante I, Lange H, Hens Z, Ayyer K.   +30 more
europepmc   +1 more source

Psychiatric supervision by direct observation

Academic Medicine, 1966
openaire   +3 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Direct observation of a doubly destabilized cation

ARKIVOC, 2012
Hanan Afifi, Alexandre Mikhailine, Gabriela Mladenova, Andrei Chtchemelinine, Israt Sultana, Tatiana Dyblenko, Evgeny Danilov, Rene Fournier, Edward Lee-Ruff   +8 more
doaj   +1 more source

Direct observation of two-channel photodissociation of carbon monoxide from the hemoglobin subunits. [PDF]

Nat Commun
Lepeshkevich SV, Sazanovich IV, Parkhats MV, Gilevich SN, Yantsevich AV, Weinstein JA, Towrie M, Dzhagarov BM.   +7 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source