Results 121 to 130 of about 730,650 (301)

Immigrant Job Search in the UK [PDF]

Most immigrant groups in the UK experience higher unemployment rates than otherwise similar UK born whites. Empirical research to date has attributed this finding to discrimination, lack of English Language fluency and the (non-) transferability of ...
Michael A Shields, Wheatley Price, Stephen   +1 more
core  

Boosting Performance of SVM in Koi Classification Using Direct Methods-Based Optimization

JOIV: International Journal on Informatics Visualization
Many koi fish enthusiasts keep or buy them just for their attractive colors without knowing what type of koi fish they are. The manual classification of koi fish species is still frequently incorrect.
Muhammad Hafizh Arkananta, Wikky Fawwaz Al Maki   +1 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Eine Studie im Bereich Direct Policy Search [PDF]

, 2010
Reinforcement learning in partially observable environments is an important and challenging problem. Since many value function-based methods have been shown to perform poorly, we study direct policy search methods instead.
Wierstra, Daniel
core  

Direct position determination of moving targets based on DOA

Electronics Letters
Compared with the traditional two‐step localization methods, the direct position determination (DPD) method is more robust at low signal‐to‐noise ratio.
Shuming He, Yuan Jiang, Lei Zhao, Guorui Lin, Bo Peng   +4 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Finding local optima of high-dimensional functions using direct search methods [PDF]

This paper focuses on a subclass of box-constrained, non-linear optimization problems. We are particularly concerned with settings where gradient information is unreliable, or too costly to calculate, and the function evaluations themselves are very ...
Glover, Fred, Hvattum, Lars Magnus
core  

Simple Complexity Analysis of Simplified Direct Search [PDF]

, 2014
We consider the problem of unconstrained minimization of a smooth function in the derivative-free setting using. In particular, we propose and study a simplified variant of the direct search method (of direction type), which we call simplified direct ...
Richtárik, Peter, Konečný, Jakub
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source