Results 121 to 130 of about 730,500 (301)

Simple Complexity Analysis of Simplified Direct Search [PDF]

, 2014
We consider the problem of unconstrained minimization of a smooth function in the derivative-free setting using. In particular, we propose and study a simplified variant of the direct search method (of direction type), which we call simplified direct ...
Richtárik, Peter, Konečný, Jakub
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Direct search methods using orthogonal directions: the Rosenbrock method and the David, Swann, and Campey method

, 1988
The Rosenbrock Algorithm and the D. S. C. Algorithm, both direct search methods using orthogonal directions were implemented into a software. Values of the optimal parameters were determined and the performance was compared with each other and with the ...
San Luis, Jonas Marcos B
core  

Comparative Evaluation of Machine Learning and Hyperparameter Optimization Methods for Low-Cost CO₂ Sensor Calibration in Terms of Performance and Computational Cost

Sensors
Low-cost sensors (LCSs) are increasingly used in air quality monitoring because of their affordability and scalability; however, their limited accuracy necessitates reliable calibration approaches. Although machine learning (ML)-based calibration methods
Eren Cihan Karsu Asal, Mehmet Taştan, Hayrettin Gökozan, Müge Erel-Özçevik, Yusuf Özçevik   +4 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Improved New Two-Spectral Conjugate Gradient Iterative Technique for Large Scale Optimization

Mağallaẗ Al-kūfaẗ Al-handasiyyaẗ
Numerous strategies have been proposed in the field of unconstrained optimization to address various optimization challenges, particularly those associated with large-scale systems. Among the classical methods, Newton and Quasi-Newton approaches are well-
Radhwan Basem Thanoon, Ghada Moayid Al-Naemi   +1 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Quantum Enhancements for Direct Search Methods

This dissertation explores the use of quantum search algorithms to im- prove direct search methods for single and multiobjective optimization. Quantum search algorithms are known to reduce the expected number of oracle calls needed to find the solution ...
Mikes, Colton
core  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source