Results 151 to 160 of about 730,500 (301)

Finding local optima of high-dimensional functions using direct search methods

This paper focuses on a subclass of box-constrained, non-linear optimization problems. We are particularly concerned with settings where gradient information is unreliable, or too costly to calculate, and the function evaluations themselves are very ...
Glover, Fred, Hvattum, Lars Magnus
core  

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Effectiveness of Guideline-Based Clinical Decision Support Systems: Protocol for a Systematic Review. [PDF]

JMIR Res Protoc
Aksu BN, Gashi B, Schiefenhövel F, Boeker M.   +3 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Preconception and first-trimester metformin for improving pregnancy outcomes in women with polycystic ovary syndrome. [PDF]

Cochrane Database Syst Rev
Devall AJ, Cheshire J, Periyathambi N, Garg A, Vigneswaran K, Melo P, Dhillon-Smith R, Coomarasamy A.   +7 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Causality relations between foreign direct investment and portfolio investment volatility

Following the liberalization of financial markets, Goldstein and Razin (2006) show that there is an information based trade-off between foreign direct investment and foreign portfolio investment, our paper examines the causality relations between foreign
Gozgor, Giray, Erzurumlu, Yaman O.
core  

Non-pharmacological interventions for anxiety and depression in Parkinson's disease. [PDF]

Cochrane Database Syst Rev
Li T, Shi J, Zheng Q, Xu JG, Zhang M, Ren Y, Zhang B, Li Z.   +7 more
europepmc   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Terminology, retrieval bias, and field definition in forensic genetic genealogy. [PDF]

Forensic Sci Int Synerg
Mittelman D, Budowle B, Mittelman K.
europepmc   +1 more source