Results 241 to 250 of about 4,150,724 (291)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Contribution of Indoor Air and Dust to Children's Per- and Polyfluoroalkyl Substance Exposure in the Faroe Islands. [PDF]

Environ Sci Technol
Woodward M, Becanova J, Vojta S, Weihe P, Grandjean P, Lohmann R.   +5 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Species Accumulation Stabilizes the Synchronous Responses to the Environment of Vertebrate Communities Worldwide. [PDF]

Ecol Evol
Picó S, Almaraz P, Godoy O.
europepmc   +1 more source

Associations Between Otic Cytological Findings and Clinical Severity by Pathogen Group in Canine Otitis Externa: A Retrospective Study of 318 Cases. [PDF]

Vet Dermatol
Shin ES, Kang SY, Kim MS, Hwang CY.
europepmc   +1 more source

Muscle coactivation-inspired stiffness-driven control strategy for antagonistic soft robots. [PDF]

Sci Adv
Pan J, Chen T, Li J, Wang Y.
europepmc   +1 more source

Adaptive Vibrational Coordinates <i>via</i> Symmetry-Aware Normalizing Flows. [PDF]

J Chem Theory Comput
Vogt E, Fernández Corral Á, Saleh Y.
europepmc   +1 more source

Assessment of Glucose Metabolism In Vivo in the Human Frontal Lobe Using Interleaved ¹ H and ¹³ C MRS at 7T: Toward Clinical Translation

Xiao Y, Wenz D, Bègue I, Hagmann P, Duarte JMN, Mattera L, Philippe N, Kaiser A, Pierzchala K, Döring A, Widmaier M, Do KQ, Gruetter R, Karampinos DC, Xin L.   +14 more
europepmc   +1 more source

Trauma Symptoms as a Bridge: Linking Early Adversities to Interpersonal Risk Profiles for Victimization and Perpetration in Women. [PDF]

Clin Neuropsychiatry
Visco-Comandini F, Papa C, Ciringione L, Franquillo AC, Tittarelli E, Mancini F, Pugliese E.   +6 more
europepmc   +1 more source

Raising the bar: a systems approach to promoting good wellbeing and self-efficacy in zoo and aquarium professionals. [PDF]

Front Vet Sci
Brando S, Buchanan-Smith HM, Rey Planellas S, Caes L.   +3 more
europepmc   +1 more source