Results 201 to 210 of about 639,311 (260)

Schubert cells and Whittaker functionals for GL ( r , R ) part I: Combinatorics. [PDF]

Manuscr Math
Kim D.
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Facilitators and Barriers to Implementing a Remote Monitoring Model of Care for Stable Patients With Axial Spondyloarthritis Using the Consolidated Framework for Implementation Research: Qualitative Study. [PDF]

J Med Internet Res
Kwan YH, Chew XR, Zainal H, Xiong Z, Hock M, Zee KH, Leung YY, Østbye T, Low LL, Goh H, Sum CWY, Yoon S, Wang CTM, Fong W, Thumboo J.   +14 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Genetic architecture of swine inflammation and necrosis syndrome and its genetic correlation with repeated skin damage scores. [PDF]

J Anim Sci
Oliveira Garcia A, Galoro Leite N, Vogelzang R, Bretanha Rocha RF, Facioni Guimarães SE, Lourenco D.   +5 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Koopman mode decomposition of thermodynamic dissipation in nonlinear Langevin dynamics. [PDF]

Proc Natl Acad Sci U S A
Sekizawa D, Ito S, Oizumi M.
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Metadensity Functional Learning for Classical Fluids: Regularizing with Pair Correlations. [PDF]

J Phys Chem B
Kampa SM, Sammüller F, Schmidt M.
europepmc   +1 more source