Results 171 to 180 of about 43,448 (306)

Proposal of a procedure to stratify the reidentification risk of medical data: RIMEDA. [PDF]

BMC Med Inform Decis Mak
Behre S, Kesztyüs D, Schnabel S, Kesztyüs T.   +3 more
europepmc   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Cost-Effectiveness of Dimethyl Fumarate Versus Teriflunomide in Patients With Relapsing-Remitting Multiple Sclerosis (RRMS) in Iran. [PDF]

Health Sci Rep
Poursadeghfard M, Farjah Y, Rezaee M, Momtahan N, Morowvat MH, Gholami A, Keshavarz K.   +6 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Scaling and quantization of large-scale foundation model enables resource-efficient predictions in network biology. [PDF]

Nat Comput Sci
Chen H, Venkatesh MS, Gόmez Ortega J, Mahesh SV, Nandi TN, Madduri RK, Pelka K, Theodoris CV.   +7 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Computational Strategy for Analyzing Effective Properties of Random Composites-Part III: Machine Learning. [PDF]

Materials (Basel)
Mityushev V, Drygaś P, Walusiak Ł.
europepmc   +1 more source

Inverse Theorems for Subset Sums

, 1994
Let A be a finite set of integers. For h 1, let S h (A) denote the set of all sums of h distinct elements of A. Let S(A) denote the set of all nonempty sums of distinct elements of A.
Melvyn B. Nathanson
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Socioeconomic inequalities in health-related quality of life during the COVID-19 pandemic: a six-country comparison using the EQ-5D-5 L. [PDF]

Qual Life Res
Eijkens J, Bonsel JM, Feng YS, Janssen MFB, Lubetkin EI, Haagsma JA.   +5 more
europepmc   +1 more source