Results 251 to 260 of about 43,448 (306)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Some Results on Cumulative Residual Inaccuracy Measure of k-Record Values. [PDF]

Entropy (Basel)
Goel R, Kumar V, Vehale S, Scott TC.
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Personalized polygenic profiling based on the genetic architecture of lipid metabolism in the Russian population. [PDF]

Front Cardiovasc Med
Mamchur A, Bruttan M, Daniel V, Kashtanova D, Zelenova E, Dzhumaniiazova I, Ivanov M, Matkava L, Blinova O, Mitrofanov S, Golubnikova L, Kumar N, Maralova E, Shingaliev A, Ezhov M, Meshkov A, Chubykina U, Pogorelova O, Tripoten M, Balahonova T, Viskova A, Komarova M, Gurtsiev T, Gomyranova N, Vorobeva Y, Hotuleva A, Kolyaskina M, Yudin V, Makarov V, Keskinov A, Kuzmina L, Boytsov S, Yudin S, Skvortsova V.   +33 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Preoperative Classification of Submembrane Spaces for Optical Coherence Tomography-Guided Epiretinal Membranectomy. [PDF]

J Vitreoretin Dis
Almeida DRP, Chin EK, Mahajan VB.
europepmc   +1 more source

Learning Continuous Decomposable Models Using Mutual Information and Statistical Copulas. [PDF]

Entropy (Basel)
Desuó Neto L, de Oliveira Caetano H, de Souza Sant'Anna Fogliatto M, Dias Maciel C.   +3 more
europepmc   +1 more source

The role of awareness, appreciation, and communication satisfaction in shaping employee engagement: evidence from the organizational health behavior index. [PDF]

Front Psychol
Alzuman A, Jaafari M, Ali Z, Ali R, Bakadam LI.   +4 more
europepmc   +1 more source

Replicability of Functional Brain Networks: A Study Through the Lens of Seven Resting-State Networks. [PDF]

Hum Brain Mapp
Fales KR, Zhi X, Song H, Lazar NA.
europepmc   +1 more source

Very long-chain saturated fatty acids in plasma lipids: association with cardiometabolic risk influenced by lipid interactions. [PDF]

Cardiovasc Diabetol
Domínguez-López I, Eichelmann F, Prada M, Schulze MB.   +3 more
europepmc   +1 more source