Results 141 to 150 of about 1,378,738 (338)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Developing and validating an implantable suture tension sensor

Heliyon
Introduction: Suture tension has a direct influence on the sutured tissue. For abdominal wall closure, suture tension should be optimal without causing tissue necrosis, which can result in surgical site infection or incisional hernia.
F.P.J. den Hartog, Y. Yurtkap, J. Vlot, J.F. Lange, P.J. Tanis, G.J. Kleinrensink   +5 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Effect of surfactant surface and interfacial tension reduction on infiltration into hydrophobic porous media

Geoderma
Surfactant molecules increase the infiltration rate into hydrophobic porous media by lowering the infiltrating water's surface tension and the interfacial tension between hydrophobic surfaces and water molecules.
Felix A. Ogunmokun, Rony Wallach
doaj   +1 more source

The Effects Of Aggregate Sizes And Fiber Volume Fraction On Bending Toughness And Direct Tension Of Steel Fiber Reinforced Concrete

, 2012
Hyun-Woo Cho, Jae-Heum Moon, Jang-Hwa Lee   +2 more
openalex   +2 more sources

Direct Measurement of Curvature-Dependent Surface Tension in a Capillary-Condensed Alcohol Nanomeniscus [PDF]

, 2020
Dohyun Kim, Jong-Woo Kim, Jonggeun Hwang, Dongha Shin, Sangmin An, Wonho Jhe   +5 more
openalex   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Fracture Parameters of Cement Mortar with Different Structural Dimensions Under the Direct Tension Test. [PDF]

Materials (Basel), 2019
Rhee I, Lee JS, Roh YS.
europepmc   +1 more source

Hidden monopole dark matter via axion portal and its implications for direct detection searches, beam-dump experiments, and the H0 tension [PDF]

, 2020
Ryuji Daido, Shu-Yu Ho, Fuminobu Takahashi   +2 more
openalex   +1 more source