Results 91 to 100 of about 471,262 (280)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Interactive Visualization of the Largest Radioastronomy Cubes

, 2010
3D visualization is an important data analysis and knowledge discovery tool, however, interactive visualization of large 3D astronomical datasets poses a challenge for many existing data visualization packages.
A.H. Hassan, Barnes, Becciani, Beeson, C.J. Fluke, D.G. Barnes, Drebin, Goel, Graham, Hamada, Lacroute, Levoy, Li, Lombeyda, McClure-Griffiths, Oosterloo, Pence, Sabella, Samet, Schive, Thibault, Wayth   +21 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Real-time volume rendering for three-dimensional fetal ultrasound using volumetric photon mapping

Visual Computing for Industry, Biomedicine, and Art
Three-dimensional (3D) fetal ultrasound has been widely used in prenatal examinations. Realistic and real-time volumetric ultrasound volume rendering can enhance the effectiveness of diagnoses and assist obstetricians and pregnant mothers in ...
Jing Zou, Jing Qin
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Catheter insertion simulation with co-registered direct volume rendering and haptic feedback [PDF]

, 2000
We have developed an experimental catheter insertion simulation system supporting head-tracked stereoscopic viewing of volumetric anatomic reconstructions registered with direct haptic 3D interaction. The system takes as input data acquired with standard
Gobbetti, Enrico, Tuveri, Massimiliano, Zanetti, Gianluigi, Zorcolo, Antonio   +3 more
core  

Shape: A 3D Modeling Tool for Astrophysics

, 2010
We present a flexible interactive 3D morpho-kinematical modeling application for astrophysics. Compared to other systems, our application reduces the restrictions on the physical assumptions, data type and amount that is required for a reconstruction of ...
Koning, Nicholas, Magnor, Marcus, Morisset, Christophe, Steffen, Wolfgang, Wenger, Stephan   +4 more
core   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

From screen to space: evaluating Siemens’ Cinematic Reality application for medical imaging on the Apple Vision Pro

Frontiers in Virtual Reality
IntroductionAs one of the first research teams with full access to Siemens’ Cinematic Reality, we evaluated its usability and clinical potential for cinematic volume rendering on the Apple Vision Pro.MethodsWe visualized venous-phase liver computed ...
Gijs Luijten, Gijs Luijten, Gijs Luijten, Lisle Faray de Paiva, Sebastian Krueger, Alexander Brost, Laura Mazilescu, Ana Sofia Santos, Peter Hoyer, Jens Kleesiek, Jens Kleesiek, Jens Kleesiek, Jens Kleesiek, Jens Kleesiek, Jens Kleesiek, Sophia Marie-Therese Schmitz, Ulf Peter Neumann, Ulf Peter Neumann, Jan Egger, Jan Egger, Jan Egger, Jan Egger, Jan Egger   +22 more
doaj   +1 more source

Horizontal Vortex Tubes near a Simulated Tornado: Three-Dimensional Structure and Kinematics

Atmosphere, 2019
Supercell thunderstorms can produce a wide spectrum of vortical structures, ranging from midlevel mesocyclones to small-scale suction vortices within tornadoes.
Maurício I. Oliveira, Ming Xue, Brett J. Roberts, Louis J. Wicker, Nusrat Yussouf   +4 more
doaj   +1 more source