Results 191 to 200 of about 20,647 (260)

Target Trial Emulation in Observational Research—Strengths, Limitations, and Methodological Considerations

open access: yesJournal of Periodontal Research, EarlyView.
The target trial framework is a pragmatic roadmap for observational causal inference that clarifies questions, mitigates time‐related bias, and improves interpretability while acknowledging limits. With transparent protocols, appropriate methods, and suitable data, it can complement randomized trials and inform practice and policy.
Sebastian‐Edgar Baumeister   +6 more
wiley   +1 more source

Study Design in Clinical and Epidemiologic Research: Observational, Experimental, and Beyond

open access: yesJournal of Periodontal Research, EarlyView.
Population‐based epidemiology and clinical research are complementary and mutually reinforcing: Epidemiology quantifies disease incidence/prevalence and elucidates environmental and social determinants in populations, whereas clinical research evaluates biomarkers, therapeutics, and prognostic outcomes in patients; their convergence underpins ...
Gustavo G. Nascimento   +3 more
wiley   +1 more source

The association between COVID‐19 vaccines and bullous pemphigoid risk: A UK population‐based study

open access: yes
Journal of the European Academy of Dermatology and Venereology, EarlyView.
Mikolaj Swiderski   +7 more
wiley   +1 more source

‘The Simpsons’ Did It Again! Periodontitis and Tooth Loss Predict Mortality in Springfield: A Retrospective Cohort Study

open access: yesJournal of Periodontal Research, EarlyView.
The IMPOSTERS study analysed 150 recurring ‘human’ Simpsons characters and found that periodontitis or tooth loss was associated with a 23‐fold higher hazard of all‐cause mortality. This was reported in the Simpsons universe, with the death of ‘Bleeding Gums’ Murphy, 3 years before the first such reports in our universe.
Praveen Sharma, Thomas Dietrich
wiley   +1 more source

Causal Inference in Clinical Research: A Primer

open access: yesJournal of Periodontal Research, EarlyView.
Causal inference helps researchers move beyond describing associations to answering the question: what would happen if an exposure were changed? This article provides an intuitive overview for applied researchers. ABSTRACT The study of causal relationships is central to scientific inquiry. Understanding what disease is, why it arises, and how it can be
Nasir Z. Bashir   +3 more
wiley   +1 more source

Cohort and Case–Control Studies: Strengths, Limitations and Methodological Considerations

open access: yesJournal of Periodontal Research, EarlyView.
Population‐based epidemiology and clinical research are complementary by design—and nowhere is that more evident than in cohort studies. By following individuals over time, cohorts quantify disease incidence, elucidate environmental and social determinants and evaluate biomarkers and prognostic outcomes within a single longitudinal framework.
Nasir Z. Bashir   +4 more
wiley   +1 more source

Insomnia and Snoring in Relation to Future Psychological Distress and Daytime Symptoms in Women

open access: yesJournal of Sleep Research, EarlyView.
ABSTRACT Anxiety, depression and daytime symptoms (sleepiness, tiredness) are overrepresented in people with snoring and insomnia, but the associations are not completely understood. We aimed to investigate relationships between insomnia and snoring with future psychological distress and daytime symptoms.
Galileo Frustaci   +2 more
wiley   +1 more source

Causal Directed Acyclic Graphs to Mitigate Confounding Bias in Exposure-Response Analyses. [PDF]

open access: yesCPT Pharmacometrics Syst Pharmacol
Goulooze SC   +4 more
europepmc   +1 more source

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