Results 161 to 170 of about 117,629 (216)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

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A NOTE ON AUTOMORPHISM GROUPS OF DIRECT PRODUCT GROUPS

Missouri Journal of Mathematical Sciences, 2022
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Gao, Mingchu, An, Guimei
openaire   +1 more source

On the Group of a Directed Graph

Canadian Journal of Mathematics, 1966
In 1938, Frucht (2) proved that for any given finite group G there exists a finite symmetric graph X such that G(X) is abstractly isomorphic to G. Since G(X) is a permutation group, it is natural to ask the following related question : If P is a given finite permutation group, does there exist a symmetric (and more generally a directed) graph X such ...
openaire   +1 more source

Patient group directions

Emergency Nurse, 2010
The patient group directions (PGD) website, which is part of the National electronic Library for Medicines (NeLM), is the national resource in England for healthcare professionals who work with, or who are involved in the development or review of, PGDs.
openaire   +2 more sources

On Direct Products of Abelian Groups

Canadian Journal of Mathematics, 1970
In this paper we investigate the properties of the product (or complete direct sum) of torsion Abelian groups. The chief results concern products of Abelian primary groups (p-groups). Given a set of p-groups, [Gλ], over an index set Λ, the product of these groups is written λλ∈ΔGλ, the torsion subgroup of the product of these p-groups is written T[λGλ],
Irwin, John M., O'Neill, John D.
openaire   +2 more sources

Direct Cancellation of Finite Groups

Algebra Colloquium, 2005
We prove that if F is a finite group, and G and H are finitely generated groups with finite commutator subgroups for which F × G ≃ F × H, then G ≃ H.
Fransman, Andrew, Witbooi, Peter
openaire   +2 more sources