Results 241 to 250 of about 679,253 (302)

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

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Patient group directions

Emergency Nurse, 2010
The patient group directions (PGD) website, which is part of the National electronic Library for Medicines (NeLM), is the national resource in England for healthcare professionals who work with, or who are involved in the development or review of, PGDs.
openaire   +2 more sources

Direct Cancellation of Finite Groups

Algebra Colloquium, 2005
We prove that if F is a finite group, and G and H are finitely generated groups with finite commutator subgroups for which F × G ≃ F × H, then G ≃ H.
Fransman, Andrew, Witbooi, Peter
openaire   +2 more sources

A NOTE ON AUTOMORPHISM GROUPS OF DIRECT PRODUCT GROUPS

Missouri Journal of Mathematical Sciences, 2022
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Gao, Mingchu, An, Guimei
openaire   +1 more source

Acetoxyl Group Directed Cyclization Promoted by SmI₂:  Directing Group Determined Stereocomplementarity

The Journal of Organic Chemistry, 2004
Complete reversal of diastereoselectivity was observed in the SmI(2)-promoted ketyl-olefin coupling cyclizations of the hydroxy ketone or aldehyde and its acetate. For example, the stereodivergent synthesis of the epimeric five-membered-ring alcohols 2 and 4 has been accomplished through the SmI(2)-induced ketyl-olefin coupling cyclizations of the ...
Toshiyuki, Kan, Seijiro, Hosokawa, Shinji, Nara, Hiroaki, Tamiya, Haruhisa, Shirahama, Fuyuhiko, Matsuda   +5 more
openaire   +2 more sources

Directoids and directed groups

Algebra Universalis, 1995
\textit{J. Ježek} and \textit{R. Quackenbush} [ibid. 27, No. 1, 49-69 (1990; Zbl 0699.08002)] have introduced directoids as groupoids corresponding exactly to up-directed posets (viz \(a \leq b\) iff \(ab = b\)). In this paper, this concept is further investigated, both in its own and in combination with an abelian group structure.
Gardner, B. J., Parmenter, M. M.
openaire   +2 more sources

Directed Intermolecular Carbomagnesation across Vinylsilanes: 2-PyMe2Si Group as a Removable Directing Group

Angewandte Chemie International Edition, 2001
Facile addition of primary alkyl Grignard reagents to vinylsilanes has been realized for the first time by exploiting the directing effect of a 2-pyridyl group on silicon [Eq. (1)]. Three-component coupling reactions of a Grignard reagent, the vinylsilane, and an electrophile, followed by oxidative removal of the 2-pyridyldimethylsilyl group with H2 O2
Itami, K, Mitsudo, K, Yoshida, J
openaire   +2 more sources