Results 241 to 250 of about 9,893,032 (297)

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

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A NOTE ON AUTOMORPHISM GROUPS OF DIRECT PRODUCT GROUPS

Missouri Journal of Mathematical Sciences, 2022
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Gao, Mingchu, An, Guimei
openaire   +1 more source

On the Group of a Directed Graph

Canadian Journal of Mathematics, 1966
In 1938, Frucht (2) proved that for any given finite group G there exists a finite symmetric graph X such that G(X) is abstractly isomorphic to G. Since G(X) is a permutation group, it is natural to ask the following related question : If P is a given finite permutation group, does there exist a symmetric (and more generally a directed) graph X such ...
openaire   +1 more source

Patient group directions

Emergency Nurse, 2010
The patient group directions (PGD) website, which is part of the National electronic Library for Medicines (NeLM), is the national resource in England for healthcare professionals who work with, or who are involved in the development or review of, PGDs.
openaire   +2 more sources

On Direct Products of Abelian Groups

Canadian Journal of Mathematics, 1970
In this paper we investigate the properties of the product (or complete direct sum) of torsion Abelian groups. The chief results concern products of Abelian primary groups (p-groups). Given a set of p-groups, [Gλ], over an index set Λ, the product of these groups is written λλ∈ΔGλ, the torsion subgroup of the product of these p-groups is written T[λGλ],
Irwin, John M., O'Neill, John D.
openaire   +2 more sources

Direct Cancellation of Finite Groups

Algebra Colloquium, 2005
We prove that if F is a finite group, and G and H are finitely generated groups with finite commutator subgroups for which F × G ≃ F × H, then G ≃ H.
Fransman, Andrew, Witbooi, Peter
openaire   +2 more sources