Results 61 to 70 of about 1,089,345 (300)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Graph signal processing for narrowband direction of arrival estimation [PDF]

, 2023
For direction of arrival (DOA) estimation based on graph signal processing (GSP), it has been assumed that there is a phase shift between adjacent snapshots of the received signals.
Mitchell, P.D., Zakharov, Y., Li, D., Liu, W.   +3 more
core   +1 more source

Direction-of-arrival estimation for constant modulus signals

IEEE Transactions on Signal Processing, 1999
In many cases where direction finding is of interest, the signals impinging on an antenna array are known to be phase modulated and, hence, to have a constant modulus (CM). This is a strong property; by itself, it is already sufficient for source separation and can be used to construct improved direction finding algorithms. We first derive the relevant
Amir Leshem, Alle-Jan van der Veen
openaire   +5 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Broadband angle of arrival estimation methods in a polynomial matrix decomposition framework

, 2013
A large family of broadband angle of arrival estimation algorithms are based on the coherent signal subspace (CSS) method, whereby focussing matrices appropriately align covariance matrices across narrowband frequency bins.
Mohamed Alrmah, Weiss, Stephan, Stephan Weiss, Mostafa Kaveh, Sangarapillai Lambotharan, McWhirter, John G., Lambotharan, Sangarapillai, Alrmah, Mohamed, Kaveh, Mostafa, John G. McWhirter   +9 more
core   +1 more source

Underdetermined direction-of-arrival estimation using super nested array

The Journal of Engineering, 2019
Among various sparse-arrays, super nested array (SNA) is found to be more attractive because it can achieve large degrees-of-freedom (DOFs) and alleviate the mutual coupling. This article address the problem of direction-of-arrival (DOA) estimation under
Zheng-Ming Jiang, Peichang Zhang, Lei Huang, Jihong Zhang   +3 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Direction-of-Arrival Estimation via Coarray With Model Errors

IEEE Access, 2018
Direction-of-Arrival (DoA) estimation with Coarray can resolve O(N2) sources via only O(N) physical sensor elements. When it comes to model errors, i.e., manual coupling, gain and/or phase errors, and sensor location errors, whether Coarray is still ...
Rui Lu, Ming Zhang, Xiaobo Liu, Xiaoming Chen, Anxue Zhang   +4 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Robust direction-of-arrival estimation in non-Gaussian noise [PDF]

, 1998
In this correspondence, a nonlinearly weighted least-squares method is developed for robust modeling of sensor array data. Weighting functions for various observation noise scenarios are determined using maximum likelihood estimation theory ...
Çetin, A. Enis, Cadzow, J. A., Yardımcı, Y.   +2 more
core   +1 more source