Results 81 to 90 of about 716,657 (292)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Using spherical wavelets to search for magnetically-induced alignment in the arrival directions of ultra-high energy cosmic rays

open access: yes, 2013
Due to the action of the intervening cosmic magnetic fields, ultra-high energy cosmic rays (UHECRs) can be deflected in such a way as to create clustered energy-ordered filamentary structures in the arrival direction of these particles, the so-called ...
Batista, R. Alves, Kemp, E., Zimbres, M.
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Root-MUSIC-based joint TOA and DOA estimation in IR-UWB

open access: yesTongxin xuebao, 2014
The parameters can be estimated via two-dimensional (2D) multiple signal classification (MUSIC) algorithm, in which the two-dimensional spectral peak searching, however, requires much higher computational complexity.
Fang-qiu WANG, Xiao-fei ZHANG, Fei WANG
doaj   +2 more sources

Fast estimation of array shape and direction of arrival using sparse Bayesian learning for manoeuvring towed line array

open access: yesIET Radar, Sonar & Navigation
The sparse Bayesian learning (SBL) algorithm has demonstrated its advantage in the direction of arrival (DOA) estimation. However, it requires a lot of computational cost to iteratively estimate the SBL hyperparameters from measurement data.
Xiang Pan   +5 more
doaj   +1 more source

Observation of the anisotropy in arrival direction of Cosmic Rays with IceCube

open access: yes, 2010
The IceCube Neutrino Observatory is a kilometer-scale detector currently under construction at the South Pole. In its final configuration the detector will comprise 5160 Digital Optical Modules (DOMs) deployed on 86 strings between 1.5-2.5 km deep within
Toscano, S.
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Direction of arrival measurements at UHF

open access: yesElectronics Letters, 1989
Direction of arrival measurements have been made at 870 MHz in an urban environment. Examples are given showing the multipath components arriving at the receiver after reflection and scattering from buildings. A synthetic aperture technique is used to measure the directions of arrival.
P.A. Matthews, B. Mohebbi
openaire   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

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