Results 81 to 90 of about 1,078,062 (309)
Nature Methods, 2006 Many young scientists know the pain of unsuccessfully lobbying an advisor to back an 'impractical' experimental approach, and David Schwartz was no exception. While working on his senior research project at Harvard University in the late 1970s, he had conceived of a method for separating DNA molecules of unprecedented size by electrophoresis, using ...
openaire +1 more source
Predicting the direction of change in aggregate demand growth and its components [PDF]
In this study, we set up a framework to generate the forecasts of growth in aggregate demand and its components using real-time data. In general, these forecasts (for 1983-2008) accurately predict directional change under symmetric loss and are thus of ...
Hamid Baghestani
core
The Amount and Direction of Change of Background Noise as a Conditioned Stimulus [PDF]
, 1964 This thesis is concerned with intensity characteristics of conditioned stimuli in acquisition of a conditioned emotional response (CER) in rats. A comparison was made of CSs which differed (between groups) with respect to amount and direction of change ...
Hilton, Anthony
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Bilateral movement asymmetries exist in recreational athletes during a 45° sidestep cut post-anterior cruciate ligament reconstruction [PDF]
PeerJIndividuals post-ACL reconstruction (ACLR) are at elevated risk for ACL re-injury. While several studies have examined biomechanical asymmetries post-ACLR during landing, less is known about asymmetries during a sidestep cut.
Montana Kaiyala +3 more
doaj +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Direction-of-change forecasting using a volatility-based recurrent neural network
, 2008 This paper investigates the profitability of a trading strategy, based on recurrent neural networks, that attempts to predict the direction-of-change of the market in the case of the NASDAQ composite index.
Bekiros, S.D. +3 more
core +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
A study of female tennis players: Speedcourt training is effective on improving agility and change-of-direction [PDF]
PeerJObjective The aim of the present paper was to determine the impact of Speedcourt training on agility and change-of-direction (COD) in female tennis players, and to research the relevance between agility and lower limbs unilateral explosive power (UEP ...
Zhihui Zhou +4 more
doaj +2 more sources