Results 41 to 50 of about 234,487 (215)
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
PHENIX results on direct photon–hadron correlations [PDF]
Nuclear and Particle Physics Proceedings, 2017 Direct photon-hadron correlations are a golden channel to study parton in-medium energy loss in QGP. The modification of the effective fragmentation function for the away-side jet can be measured by comparing integrated away-side yields of direct photon-hadron pairs in heavy ion collisions to those in p+p.
openaire +3 more sources
The multifaceted roles of lysosomes in cancer
Molecular Oncology, EarlyView.Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley +1 more source
Mbyá resultatives and the structure of causation
, 2019 In Mbyá, target state resultative predicates can only be derived from inchoative verbs. This is in contrast with target state adjectival passives in better studied languages such as English, German and Greek, which can be derived from transitive ...
Guillaume Thomas
core +1 more source
RESULTS ON DIRECT CP VIOLATION FROM NA48 [PDF]
International Journal of Modern Physics A, 2000 A report on the recent measurement of epsilon-prime, which characterises direct CP violation in the neutral kaon system, by the NA48 collaboration.
openaire +5 more sources
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
MIDAS Regressions: Further Results and New Directions
Econometric Reviews, 2006 We explore Mixed Data Sampling (henceforth MIDAS) regression models. The regressions involve time series data sampled at different frequencies. Volatility and related processes are our prime focus, though the regression method has wider applications in macroeconomics and finance, among other areas.
Eric Ghysels +2 more
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FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Non-Abelian Vortices: Results in New Directions [PDF]
Crossing the Boundaries, 2010 Two new results on non-Abelian vortices are illustrated. In the first part we discuss the construction of non-Abelian vortices in theories with general gauge groups. The second part is dedicated to the fractional vortices and lumps, which occur in a wide variety of Abelian and non-Abelian generalizations of the Higgs model.
openaire +2 more sources