Results 101 to 110 of about 4,670 (216)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Automated quantitative analysis of osteoclast numbers and areas in cell culture plates using the YOLOv8 instance segmentation model. [PDF]

MethodsX
Huang J, Li Z, Ouyang J, Li J, Fan Y, Huang D, Dong M, Jin F, Lu Y.   +8 more
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

The consequences of dismantling community-led HIV programming in Kenya: a call to action from the HEKA programme research partnership in Kenya. [PDF]

BMJ Glob Health
Walimbwa Wambaya J, Ligare F, Wanjiku J, Mwendwa K, Ouma K, Digolo V, Asuri G, Kyalo C, Macharia P, Wambui JM, Noah A, Odhiambo B, Ogalo A, Olango K, Nekesa L, Tabbu S, Tahmo N, Mishra S, Lorway RR, Lazarus L.   +19 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Grey water footprint of pharmaceuticals and personal care products discharged via urban wastewater. [PDF]

Sci Rep
Stejskalová L, Ansorge L, Rosendorf P, Fiala D, Chernysh Y, Blanco A, Minguez L, Kučera J, Břicháčková A, Vološinová D, Smetanová L, Váňa M.   +11 more
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Factors influencing the participation of people with disabilities in digital skills training in Poland. [PDF]

PLoS One
Pawłowska-Cyprysiak K, Hildt-Ciupińska K, Mockałło Z, Hamideh Kerdar S.   +3 more
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The Liability for Damage Caused by the Use of Artificial Intelligence (AI) in Medicine. [PDF]

Med Arch
Matesa B, Masic I.
europepmc   +1 more source