Results 271 to 280 of about 351,527 (346)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Evaluating milk quality indicators in the era of antimicrobial stewardship: A study of tennessee dairy farms (2011-2023). [PDF]

PLoS One
Salvador RT, Vidlund J, Okafor CC.
europepmc   +1 more source

Mother Character's Use of Directive Illocutionary Acts in 'The Croods: A New Age' Movie

Ketut Dika Widhyayukti, Putu Nur Ayomi
openalex   +2 more sources

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Principles Underlying Mental Health Legislation. [PDF]

Can J Psychiatry
O'Reilly RL, Neilson G, Dufour M, Chaimowitz G.   +3 more
europepmc   +1 more source

Prevalence and Implementation of Psychiatric Advance Directives Among Veterans With Serious Mental Illness. [PDF]

Psychiatr Res Clin Pract
McBride L, Putris N, Hagans W, Hoxey A, Oakes D, Girard V, Avila A, Treichler E.   +7 more
europepmc   +1 more source

EU air pollution policy : to what extent is the EU a particularly efficient body for air pollution policy development? : a case study of the development of the EU vehicle directives

, 1998
Therese Kloumann Tegn
openalex   +1 more source

Project DECIDE II: evaluating the efficacy of supported advance care decision making within routine care in dementia: a randomized controlled trial. [PDF]

BMC Med Ethics
Athanasiadi E, Thyrian JR, Florack J, Theile-Schürholz A, Karneboge J, Müller T, Kleinke K, Kremer S, Boes C, Böhm H, Herder-Peyrounette A, Kremer M, Sander C, Müller-Späth R, Ullrich H, Boekholt M, Hassenzahl M, Albers R, Forstmeier S, Schaper P, Haberstroh J.   +20 more
europepmc   +1 more source

Current perspectives on psychedelic treatments in Europe. [PDF]

Lancet Reg Health Eur
Madero S, Soto-Angona O, Ona G, Sanchez-Moreno J, Vieta E.   +4 more
europepmc   +1 more source

Advance care planning and hospice utilization among Japanese Americans: a scoping review. [PDF]

Proc (Bayl Univ Med Cent)
Fujioka G, Vallavanatt I, Liu J, Onishi E, Chui D.   +4 more
europepmc   +1 more source