Results 141 to 150 of about 30,845 (250)

'Everyday genetics' in the Mass Observation Project: insights on genetics from people writing for an archive of everyday life in Britain. [PDF]

Eur J Hum Genet
Horton R, Weller S, Ballard L, Lucassen A.   +3 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Insulin Prescribing in Accordance With the Guidelines for Type II Diabetes: An Analysis of Billing Data of a German Statutory Health Insurance Carrier, the Allgemeine Ortskrankenkasse (AOK) Hessen. [PDF]

Dtsch Arztebl Int
Mertes B, Zeise N, Gödde S, Kramer G, Kloos C, Klinge A, Uebel T.   +6 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Comparison Of Quasi-Steady State And Dynamic Simulation Approaches For The Calculation Of Building Energy Needs: Thermal Losses

, 2012
One of the aims of the European Directive 2010/31/EU (formerly 2002/91/EC) is to reduce the energy consumption of buildings introducing an energy labeling protocol which is expected to capture the attention and reorient the market, sustaining the ...
Gasparella, Andrea, Pernigotto, Giovanni
core  

The relationship between leadership styles of nurse managers, nurse motivation, and turnover intention among nurses in Saudi Arabia: A descriptive correlational study. [PDF]

Belitung Nurs J
Aldhafeeri NA, Alshutwi SS, Alotaibi AM, Alanaza AE, Jaber AH, Alharbi AS, Alowais RK.   +6 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Countercyclical contingent capital (CCC): possible use and ideal design [PDF]

Contingent capital – any debt instrument that converts into equity when a predefined event occurs – has received increasing attention as a viable tool for allowing banks to raise capital when needed at relatively more affordable prices than common equity.
Massimo Libertucci, Mario Quagliariello, Giuseppe De Martino, Mario Marangoni   +3 more
core  

Protecting organ donation and transplantation programmes from regulatory uncertainty: an urgent appeal to the European Parliament, Council and Commission. [PDF]

Lancet Reg Health Eur
Cuende N, Izeta A, Domínguez-Gil B.
europepmc   +1 more source