Results 101 to 110 of about 4,342,515 (278)

Corporate manslaughter and the company director [PDF]

open access: yes, 2013
On the 6th April, 2008, long-awaited legislation comes into force which will change the face of corporate accountability for manslaughter. From sullen grumblings as far back as 1912 in the wake of the Titanic disaster, there has been growing concern that
Daniels, Simon
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

One More for the Road: Director’s Notes on Exile, Family and Film, by Rajko Grlić. Berghahn Books, 2021, 346 pp.

open access: yesAlphaville: Journal of Film and Screen Media
Rajko Grlić’s book One More for the Road: Director’s Notes on Exile, Family and Film is an autobiographical view of a life, told through film terminology.
Ana Djordjevic
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Rencontre autour de Robert Wilson Bob Meets Sam

open access: yesMiranda: Revue Pluridisciplinaire du Monde Anglophone, 2016
Transcription of the round-table on Robert Wilson’s work at Théâtre Garonne (Toulouse) on February, 21th 2015. The discussion with Romain Fohr, Charles Chemin, Frédéric Maurin and the audience about Wilson’s staging of Krapp’s Last Tape was set up by the
Charles Chemin   +5 more
doaj  

The limits of Hamiltonian structures in three-dimensional elasticity, shells, and rods [PDF]

open access: yes, 1996
This paper uses Hamiltonian structures to study the problem of the limit of three-dimensional (3D) elastic models to shell and rod models. In the case of shells, we show that the Hamiltonian structure for a three-dimensional elastic body converges, in a ...
Ge, Zhong   +2 more
core  

Screening Pediatric Patients for Reading difficulties Test: Draft (SPRouT-D) Assistant Professor in Pediatrics Medical Director Medical Director Director Medical Advisor Director Medical Director Medical Director Director Medical Director

open access: yes
The Screening Pediatric Patients for Reading difficulties Test: Draft (SPRouT-D) is a brief checklist that takes two-to-three minutes to administer and is designed to assess early markers of reading disabilities/dyslexia in children from pre-K to second grade.
Eric Tridas   +4 more
openaire   +1 more source

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