Results 111 to 120 of about 369,366 (310)

Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria

Advanced Science, EarlyView.
When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley   +1 more source

Drive through COVID19 vaccination for developmentally disabled persons. [PDF]

Vaccine, 2022
Reidenberg BE, Hirsch K, Costello CM, Russo M, Reilly M, Murphy P.   +5 more
europepmc   +1 more source

Artificial Tongue-Placed Tactile Biofeedback for perceptual supplementation: application to human disability and biomedical engineering

, 2007
The present paper aims at introducing the innovative technologies, based on the concept of "sensory substitution" or "perceptual supplementation", we are developing in the fields of human disability and biomedical engineering.
Chenu, Olivier, Demongeot, Jacques, Moreau-Gaudry, Alexandre, Payan, Yohan, Vuillerme, Nicolas   +4 more
core   +1 more source

An On‐Demand Neuromorphic Vision System Enabled by a Multi‐Paradigm Neuromorphic Device and Hierarchical Reconfigurability Designed from Device to System Level

Advanced Science, EarlyView.
An on‐demand ultra‐reconfigurable intelligent vision system with hierarchical reconfigurability from device to system levels is demonstrated. Through co‐design of a multi‐paradigm device, reconfigurable circuits, and adaptive system architecture/algorithms, the system enables seamless switching among spiking, non‐spiking, neuromorphic imaging (NI), and
Biyi Jiang, Jiayi Xu, Liang Ran, Xinhe Feng, Khalil Harrabi, Yida Li, Longyang Lin, Feichi Zhou   +7 more
wiley   +1 more source

Twenty-year trends in the prevalence of disability in China

Bulletin of the World Health Organization, 2011
OBJECTIVE: To evaluate changes in the age-adjusted prevalence of disability in transitional China from 1987 to 2006. METHODS: Data from nationally representative surveys conducted in 1987 and 2006 were used to calculate age-adjusted disability prevalence
Xiaoying Zheng, Gong Chen, Xinming Song, Jufen Liu, Lijing Yan, Wei Du, Lihua Pang, Lei Zhang, Jilei Wu, Bingzi Zhang, Jun Zhang   +10 more
doaj  

Hearing loss prevalence and burden of disease in China: Findings from provincial-level analysis

Chinese Medical Journal
. Background:. Without timely and effective rehabilitation, hearing loss may profoundly affect human life quality. China has a large population of hearing-impaired individuals, which imposes a heavy health burden on society. Moreover, this population is
Yu Wang, Yang Xie, Minghao Wang, Mengdan Zhao, Rui Gong, Ying Xin, Jia Ke, Ke Zhang, Shaoxing Zhang, Chen Du, Qingchuan Duan, Fang Wang, Tao Pan, Furong Ma, Xiangyang Hu, Jing Ni   +15 more
doaj   +1 more source

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

Advanced Science, EarlyView.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian, Xiao‐Long Wang, Li Yin, Wei Wei, Xue Li, Yao Ge, Zhao‐Xia Xiang, Na Tian, Li‐Juan Chen, Ming‐Wei Ma, Xia Zhang, Xu Jing, Mei‐Yun Wang, Xu‐Feng Xu   +13 more
wiley   +1 more source

Evaluating Stroke-Related Motor Impairment and Recovery Using Macroscopic and Microscopic Features of HD-sEMG

Bioengineering
Stroke-induced motor impairment necessitates objective and quantitative assessment tools for rehabilitation planning. In this study, a gesture-specific framework based on high-density surface electromyography (HD-sEMG) was developed to characterize ...
Wenting Qin, Xin Tan, Yi Yu, Yujie Zhang, Zhanhui Lin, Chenyun Dai, Yuxiang Yang, Lingyu Liu, Lingjing Jin   +8 more
doaj   +1 more source

Random Time‐Space Coding Metasurfaces for Spatial Control of the Temporal Statistics of Electromagnetic Fields

Advanced Science, EarlyView.
A probabilistic framework based on random time‐space coding metasurfaces enables control of the spatial distribution of electromagnetic fields temporal statistics. By tailoring the marginal and joint distributions of random codes, electromagnetic fields with desired mean and variance patterns are realized, enabling simultaneous transmission and jamming.
Jia Cheng Li, Jiang Han Bao, Che Liu, Tie Jun Cui   +3 more
wiley   +1 more source

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source