Results 161 to 170 of about 138,716 (264)

8‐Oxoguanine Modified CircMTUS1 Drives PABPC1 Phase Separation to Promote Gastric Cancer Progression and Cisplatin Resistance via Autophagy

Advanced Science, EarlyView.
ABSTRACT Gastric cancer (GC) is a major global health concern, as its prevention and treatment remain significant challenges. The 8‐oxoguanine (o8G) modification of circRNAs, alongside their capacity to orchestrate liquid‐liquid phase separation (LLPS) and autophagy, plays a pivotal role in driving tumor progression and determining therapeutic outcomes.
Lei Peng, Lurong Li, Zhenghui Zhu, Chenyang Li, Huaiming Sang, Guoxin Zhang, Xuan Li, Yini Dang, Yuanyuan Li   +8 more
wiley   +1 more source

The mRNA export factor UAP56 is required for dendrite and synapse pruning via actin regulation in Drosophila. [PDF]

J Cell Sci
Frommeyer SM, Gigengack U, Rode S, Davies M, Wolterhoff N, Rumpf S.   +5 more
europepmc   +1 more source

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

Pentaphosphorylated magic spot nucleotides: chemoenzymatic synthesis and disassembly-based sensing.

Org Biomol Chem
Moser P, Roy SK, Herzog M, Bauer F, Wollensack F, Breit B, Jessen HJ.   +6 more
europepmc   +1 more source

Architecture-Encoded Degradation Kinetics and Pathways through the Shape and Size of Polymeric Vesicles. [PDF]

J Am Chem Soc
Wang D, Luan J, White PB, Wilson DA.
europepmc   +1 more source

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source

Light-switchable swarming of biohybrid microrobots. [PDF]

Sci Adv
de la Asunción-Nadal V, Nisula C, Cuntín-Abal C, Kobrin R, Mendis G, Latella J, Chen C, Jurado-Sánchez B, Zhang L, Escarpa A, Boisen A, Wang J.   +11 more
europepmc   +1 more source

Controlled Peptide Capture and Release in 3D‐Printed Multimaterial Microstructures

Advanced Science, EarlyView.
Two‐photon laser printing of 3D microstructures using a peptide‐containing ink is shown. The microstructures allow for controlled capture and release of target peptides through coiled‐coil interaction with the printed peptide inside the material. Based on these properties, orthogonal capture and stimuli‐mediated release possibilities inside printed ...
Niklas Schwegler, Thomas Heim, Philipp Mainik, Eva Blasco, Franziska Thomas   +4 more
wiley   +1 more source

Task complexity in exoskeleton setup and takedown: Procedural steps and usability problems as predictors of deployment performance. [PDF]

PLoS One
Sanchez-Balandran J, Fernandez AM, Tovar L, Pennathur P, Pennathur A.   +4 more
europepmc   +1 more source

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source