Results 31 to 40 of about 138,716 (264)
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
A structured index describing the ease of disassembly for handcrafted product
Cogent Engineering, 2019 Both economic and environmental aspects significantly influence the design process since the early phases of preliminary design. The total Life Cycle Assessment (LCA) and the End of Life (EoL) of products have to be defined in the early design phases too
Daniela Francia +4 more
doaj +1 more source
Optimisation of Product Recovery Options in End-of-Life Product Disassembly by Robots
Automation, 2023 In a circular economy, strategies for product recovery, such as reuse, recycling, and remanufacturing, play an important role at the end of a product’s life.
Natalia Hartono +2 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Multi-Method Model for the Investigation of Disassembly Scenarios for Electric Vehicle Batteries
Batteries, 2023 Disassembly is a pivotal technology to enable the circularity of electric vehicle batteries through the application of circular economy strategies to extend the life cycle of battery components through solutions such as remanufacturng, repurposing, and ...
Sabri Baazouzi +2 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
A Concept To Support Decision-Making In Inspection Processes of Circular Economy
Proceedings of the Conference on Production Systems and LogisticsThe consequences of climate change and current economic and political crises are presenting manufacturing companies with ever greater challenges. On the one hand, increasingly stringent regulations regarding environmental sustainability must be complied ...
Sandner, Sophie, Metternich, Joachim
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Advanced Engineering Research, 2012 The possibility of the vibrowave impact application under the connecting threads disassembly is investigated. The specified operations go to make up a considerable amount of work in the repair and recycling of engineering products.
Anatoly Prokofyevich Babichev +2 more
doaj
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source