Results 131 to 140 of about 2,757,418 (333)

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

Advanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji, Xuedan Sun, Zhangran Sun, Mengfan Li, Xinyu Cheng, Shuai Tian, Rick F. Thorne, Jinming Li, Guangzhi Liu, Mian Wu, Xiaoying Liu   +10 more
wiley   +1 more source

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
wiley   +1 more source

An Urgent Case for Higher Resolution Digital Elevation Models in the World’s Poorest and Most Vulnerable Countries

Frontiers in Earth Science, 2015
Alanna L. Simpson, Simone eBalog, Delwyn K. Moller, Benjamin eStrauss, Keiko eSaito   +4 more
doaj   +1 more source

Classifying Building Roof Damage Using High Resolution Imagery for Disaster Recovery. [PDF]

Photogramm Eng Remote Sensing, 2023
Gonsoroski E, Ahn Y, Harville EW, Countess N, Lichtveld MY, Pan K, Beitsch L, Sherchan SP, Uejio CK.   +8 more
europepmc   +1 more source

Designing to heal: post-disaster rebuilding to assist community recovery [PDF]

The physical destruction accompanying disasters typically creates an urgency to rebuild and help survivors get back on track. There are inspiring examples of how architects and other built environment professionals have contributed to rebuilding. In many
Jenny Donovan
core  

PERANCANGAN DISASTER RECOVERY CENTER (DRC) BERDASARKAN ISO 24762 (STUDI KASUS: Lembaga Penerbangan dan Antariksa Nasional (LAPAN) Bandung) [PDF]

, 2015
Lembaga Penerbangan dan Antariksa Nasional (LAPAN) Bandung merupakan instansi pemerintah yang bergerak dalam bidang pusat penelitian keantariksaan.
Doddy Ferdiansyah, DS, Iwan Kurniawan, DS, Yusuf Hamdani Suherman, Alumni   +2 more
core   +1 more source

Breaking the Toughness‐Stretchability Trade‐Off in Hydrogels with Dynamic Hydrogen Bonding

Advanced Science, EarlyView.
A novel nanocomposite hydrogel architecture overcomes the inherent conflict between toughness and stretchability by integrating uniformly dispersed aminopropyl‐hybrid‐phyllosilicate nanosheets within a polyacrylamide matrix. This design leverages a dynamic hydrogen‐bonding network to facilitate efficient energy dissipation and self‐recovery.
Yining Gao, Yong Tao, Roland J.‐M. Pellenq, Fazhou Wang   +3 more
wiley   +1 more source

Research on Key Technology and Implementation of IaaS Resource Pool Disaster Recovery

Dianxin kexue, 2012
This paper describes the principle and application of key technologies of IaaS disaster recovery scene,explores how to build the disaster recovery system of the IaaS resource pool with these key technologies,and explores the basic principles should ...
Wensheng Yao, Jun Li, Heliang Ye, Ning Wan   +3 more
doaj   +2 more sources

Peroxidase‐Mimicking Nanozymes for Rapid Detection of Infectious Diseases

Advanced Science, EarlyView.
Peroxidase‐mimicking nanozymes (PMNs) have emerged as robust and versatile materials for rapid infectious disease diagnostics. This review highlights the rational design and controlled synthesis of PMNs, summarizes key biomarkers relevant to infectious diseases, examines their integration into diverse rapid detection platforms, and highlights ...
Shikuan Shao, Victor Fernandez‐Gonzalez, Xiaochuan Wang, Blake Pylipow, Claudia Herrera, Xiaohu Xia   +5 more
wiley   +1 more source

All‐in‐One Underwater Quality Evaluation Metamaterial With Mechanical Robustness, Sound Attenuation, and Diffuse Reflection

Advanced Science, EarlyView.
In this work, a bioinspired all‐in‐one underwater quality evaluation metamaterial, combining sound attenuation, diffuse reflection, and mechanical robustness, is proposed based on jumping spider locomotion and human skeletal biomechanics. Meanwhile, a CNN‑driven quality evaluation framework is established for theoretically dimension‐reduced ...
Hongze Li, Zhenyu Li, Jinshui Yang, Jianhao Wu, Yidan Chen, Linzhi Wu, Hong Hu, Penglin Gao, Yegao Qu   +8 more
wiley   +1 more source