Results 61 to 70 of about 1,617,242 (349)

Disc cell senescence in intervertebral disc degeneration: Causes and molecular pathways

Cell Cycle, 2016
The accumulation of senescent disc cells in degenerative intervertebral disc (IVD) suggests the detrimental roles of cell senescence in the pathogenesis of intervertebral disc degeneration (IDD).
C. Feng, Huan Liu, Minghui Yang, Yang Zhang, Bo Huang, Yue Zhou   +5 more
semanticscholar   +1 more source

Generation of highly inclined protoplanetary discs through single stellar flybys

, 2015
We study the three-dimensional evolution of a viscous protoplanetary disc which is perturbed by a passing star on a parabolic orbit. The aim is to test whether a single stellar flyby is capable to excite significant disc inclinations which would favour ...
Xiang-Gruess, Meng
core   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Generation of inclined protoplanetary discs and misaligned planets through mass accretion I: Coplanar secondary discs

, 2017
We study the three-dimensional evolution of a viscous protoplanetary disc which accretes gas material from a second protoplanetary disc during a close encounter in an embedded star cluster.
Kroupa, P., Xiang-Gruess, M.
core   +1 more source

The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non‐cell‐autonomous HLS1–AMP1 signaling in a region‐specific manner

FEBS Letters, EarlyView.
The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley   +1 more source

In-Line Measurement of Particle Weight of Pulses Such as Chickpea by Piezoelectric Sensor

IEEE Access
Piezoelectric-based sensors are used as well as optical sensors for homogeneous sowing of seeds in the fields and for calculating the grain loss rate in harvesting and cleaning with harvesters in agricultural production.
Nihat Cankaya
doaj   +1 more source

Cellular Senescence in Intervertebral Disc Aging and Degeneration: Molecular Mechanisms and Potential Therapeutic Opportunities

Current Molecular Biology Reports, 2018
Age is a major risk factor for multiple disease pathologies, including chronic back pain, which stems from age-related degenerative changes to intervertebral disc tissue. Growing evidence suggests that the change in phenotype of disc cells to a senescent
Prashanta Silwal, Allison M. Nguyen-Thai, Haneef Ahamed Mohammad, Yanshan Wang, P. Robbins, Joon Y. Lee, Nam N. Vo   +6 more
semanticscholar   +1 more source

An additional soft X-ray component in the dim low/hard state of black hole binaries

, 2009
We test the truncated disc models using multiwavelength (optical/UV/X-ray) data from the 2005 hard state outburst of the black hole SWIFT J1753.5-0127. This system is both fairly bright and has fairly low interstellar absorption, so gives one of the best
Arévalo, C. Y. Chiang, Cabanac, Cadolle Bel, Chris Done, Corbel, De Matteo, Done, Done, Dunn, Durant, Esin, Esin, Fender, Fender, Frontera, Frontera, Gallo, Gandhi, Gierliński, Gierliński, Haardt, Hiemstra, Hynes, Hynes, Ingram, Kanbach, King, Kotov, Krolik, Kubota, Kubota, Körding, Lasota, Liu, Liu, M. Still, Maitra, Makishima, Malzac, Markoff, Markoff, Mayer, McClintock, McClintock, Mitsuda, Motch, Narayan, Nowak, O. Godet, Poutanen, Reis, Russell, Shahbaz, Shakura, Shapiro, Shrader, Svensson, van Paradijs, Wardziński, Wilkinson, Zdziarski, Zurita, Życki   +63 more
core   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source