Results 51 to 60 of about 10,655 (303)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Development of Thrust, Torque, and Power Estimation Model, and Prediction Performance of Earth Pressure Balance Tunnel Boring Machine in Mixed-Face Strata

Applied Sciences
In this paper, a theoretical estimation model of TBM thrust, torque, and power in the rock–soil interface (RSI) of mixed ground is developed, including a new force model for the drag cutter that accounts for chamber pressure and soil friction.
Shufang Zhai, Yingjie Song, Hao Tian
doaj   +1 more source

Theoretical Research and Simulation Analysis on the Cutter Spacing of Double Disc Cutters Breaking Rock

KSCE Journal of Civil Engineering, 2019
The arrangement of disc cutter on a cutter head is important to improve the performance of TBM (tunnel boring machine) cutter, cutter life and cutter disc bearing life, then reduce vibration of TBM and reduce the noise. The rock breaking with double disc cutters is the basis of study on the distribution of disc cutter on cutter head, and it plays an ...
Peng Zhou, Jingjing Guo, Jian Sun, Defang Zou   +3 more
openaire   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

From lab forces to field lifespans: How rock and operating parameters govern TBM disc cutter wear

Rock Mechanics Bulletin
Tunnel boring machines (TBMs) are considered a reliable and fast method for boring long tunnels. However, the wear and failure of disc cutters in hard rock influences the efficiency of equipment, ultimate timeline, and project cost. Therefore, estimating
Ehsan Mohtarami, Amin Hekmatnejad, Georg H. Erharter, Alvaro Pena   +3 more
doaj   +1 more source

Studying the Effect of Tunnel Depth Variation on the Specific Energy of TBM, Case Study: Karaj–Tehran (Iran) Water Conveyance Tunnel [PDF]

, 2016
The tunnel-boring machine (TBM) is a common piece of equipment used in tunneling projects. For planning a mechanical excavation project, prediction of TBM performance and the specification of design elements such as required forces are critical.
Dehkordi, M. S. (Mohsen), Mirahmadi, M. (Majid), Tabaei, M. (Morteza)   +2 more
core  

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

The Influence of Confining Stresses on Rock Fragmentation, Thrust Force, and Penetration Energy in Sandstone Indentation Tests Using Disc Cutters

Advances in Civil Engineering, 2021
Hard rock Tunnel Boring Machines (TBMs) engaging disc cutters as cutting tools have been employed in considerable underground coal mines to accommodate the requirement of more stone drivage as operations are going deeper.
Gaofeng Wang, Ting Ren, Gaolei Zhu
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Dynamic Rock-Breaking Process of TBM Disc Cutters and Response Mechanism of Rock Mass Based on Discrete Element

Advances in Civil Engineering, 2022
Rock-breaking efficiency of full-face rock tunnel boring machine (TBM) is closely related to the performance of the disc cutter and the characteristics of the rock mass.
Qinglong Zhang, Yanwen Zhu, Canxun Du, Sanlin Du, Kun Shao, Zhihao Jin   +5 more
doaj   +1 more source