Results 151 to 160 of about 275,030 (303)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Epidemiology and treatment trends in cervical, thoracic and lumbar disc herniation- a nationwide analysis. [PDF]

Brain Spine
Alsolivany J, Früh A, Almahozi A, Dengler N, Hecht N, Vajkoczy P, Mark-Sargut CS, Sargut TA.   +7 more
europepmc   +1 more source

Macrophage Lipid Homeostasis Drives IVDD via a Senescence‐Dependent Impairment of Efferocytosis

Cell Proliferation, EarlyView.
Intervertebral disc degeneration (IVDD) has been a leading cause of low back pain and lacks disease‐modifying therapies. Although dysregulated disc lipid metabolism is implicated, its impact on the immune microenvironment, particularly macrophages, remains unknown.
Jinyu Wang, Shiyong Ling, Qi Wang, Xuege Qiao, Jianpeng Xing, Siyang Ji, Linhui Han, Chen Yan, Zhishen Niu, Lei Yuan, Baolian Zhao, Kaiqiang Sun, Jiangang Shi   +12 more
wiley   +1 more source

Sequestered Lumbar Disc Herniation Mimicking a Spinal Tumor: A Case Report. [PDF]

Cureus
Khader G, Momotiuk I, Alkorayshi MK, Buhl R.   +3 more
europepmc   +1 more source

Ammonia Accumulation Drives Intervertebral Disc Degeneration by Triggering Ammonia‐Induced Cell Death Through Lysosome–Mitochondria Crosstalk

Cell Proliferation, EarlyView.
Mechanical strain disrupts the lysosome‐mitochondria axis via GLS1‐mediated ammonia toxicity, causing NP cell death and ECM breakdown in IVDD. CB839‐mediated GLS1 inhibition effectively rescues cellular homeostasis and alleviates disc degeneration.
Yang Zhang, Yucheng Gao, Shuhang Dong, Shuanggong Liu, Lei Liu, Ziyi Song, Jie Xu, Yijun Rong, Guangxu Song, Yingze Zhang, Dongjin Wu, Zengxin Gao   +11 more
wiley   +1 more source

Brown-Séquard syndrome caused by cervical disc herniation with associated Horner's syndrome: a case report. [PDF]

J Surg Case Rep
Park GJ, Kwon DY, Kim KR.
europepmc   +1 more source

Ηip dysplasia in children with spina bifida after prenatal surgical closure

Developmental Medicine &Child Neurology, EarlyView.
Neonatal hip morphology following prenatal closure remains poorly characterized. This study is the first to compare the prevalence of sonographically detectable hip dysplasia in children who underwent prenatal closure for spina bifida with that of the general infant population.
Domenic Grisch, Aurelia Hof, Charlotte Vlachopoulos, Spina Bifida Study Group Zurich, Barbara Casanova, Ruth Etter, Patrice Grehten, Sandra Fernandez‐Diaz, Cornelia Hagmann, Maya Horst Luethy, Raimund Kottke, Niklaus Krayenbuehl, Markus A. Landolt, Bea Latal Hajnal, Andrea Lehmann, Luca Mazzone, Andreas Meyer‐Heim, Carolin Meyer zu Spradow, Theres Moehrlen, Ueli Moehrlen, Svea Muehlberg, Timothy Müller, Beth Padden, Susanne Polentarutti, Antonin Prouza, Evelyne Riesen, Brigitte Seliner, Mithula Shellvarajah, Selma Sirin, Alexandra Wattinger, Noemi Zweifel, Lukas Kandler, Nicole Ochsenbein, Nele Struebing, Max Antonio Thomasius, Ladina Vonzun, Britta K. Krautwurst, Christos Tsagkaris, Thomas Dreher   +38 more
wiley   +1 more source

Direct Endoscopic Visualization of Gas Release in a Lumbar Disc Herniation: A Case Report. [PDF]

J Orthop Case Rep
Mendez S, Polemidiotis M, Nasr C, Justin A, Baptist AJ, Katsuura Y.   +5 more
europepmc   +1 more source

Trend of the incidence of lumbar disc herniation: decreasing with aging in the elderly

, 2013
Daoyou Ma,1 Yunbiao Liang,1 Daoming Wang,1 Zejiang Liu,1 Wei Zhang,1 Tantan Ma,1 Liang Zhang,1 Xingjun Lu,1 Zhiyou Cai21Department of Rehabilitation, the Lu'an Affiliated Hospital of Anhui Medical University, Lu'an People's Hospital, Lu' ...
Zhang W, Liu Z, Lu X, Liang Y, Wang D, Cai Z, Zhang L, Ma D, Ma T   +8 more
core  

Continuing automated insulin delivery systems during hospitalisation with type 1 diabetes: A thematic literature review

Diabetic Medicine, EarlyView.
Abstract Aims A thematic review that identifies and summarises available evidence for people with Type 1 diabetes (T1D) continuing automated insulin delivery (AID) systems in the hospital setting, primarily with a focus on assessing the in‐hospital safety and efficacy of AID use.
Hannah Cunningham, Alicia Jenkins, David N. O'Neal, Melissa H. Lee   +3 more
wiley   +1 more source