Results 41 to 50 of about 275,030 (303)

Standard Single Level discectomy; Evaluation of the Risk Factors for Recurrence

Egyptian Spine Journal, 2013
Background Data: Various surgical options exist for lumbar disc herniation. In patients who do not respond to conservative treatment, open discectomy still remains a standard method and it has been reported to have diverse outcomes.
Ehab El Gamal, Ashraf Farid
doaj   +1 more source

Laterality of cervical disc herniation [PDF]

European Spine Journal, 2012
Cervical disc herniation (CDH) is found more frequently at the lower cervical spine than at the upper or middle level. However, there is scarcity of data about the laterality of CDH. The aim of this study is to detect the laterality of CDH.We retrospectively evaluated preoperative computed tomography myelograms and magnetic resonance images of 75 cases
Yuichi, Takahashi, Takao, Yasuhara, Shinji, Kumamoto, Kotaro, Yoneda, Takashi, Tanoue, Masayuki, Nakahara, Takafumi, Inoue, Yasukazu, Hijikata, Tejin, Lee, Cesario V, Borlongan, Koichi, Ogawa, Kenki, Nishida   +11 more
openaire   +2 more sources

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

RECOVERY OF LUMBOSACRAL PAINS AFTER LUMBAR DISC HERNIATION SURGERY [PDF]

, 2017
Background. Lumbar disc herniation is a suffering with increased incidence and a tendency to continuously decrease the age at which it starts. In disc disorders where pain is accentuated during walking and resting and does not give in to medical and ...
Anca JIANU
core   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

An Investigation Into the Relationship Between the Sedimentation Sign and Lumbar Disc Herniation in Upright Magnetic Resonance Images

Global Spine Journal
Study Design Retrospective Upright MRI Study. Objectives Determine the relationship between lumbar disc herniation and presence of the nerve root sedimentation sign on upright kinematic MRI patients.
Kishan Patel BS, Seung Min Son MD, PhD, Qiwen Zhang BS, Jeffrey C. Wang MD, Zorica Buser PhD, MBA   +4 more
doaj   +1 more source

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

Factors related to the postoperative recurrence of lumbar disc herniation treated by percutaneous transforaminal endoscopy: A meta-analysis

Frontiers in Surgery, 2023
ObjectiveTo explore factors related to the postoperative recurrence of lumbar disc herniation treated by percutaneous transforaminal endoscopy.MethodsPubMed, EMBASE, Cochrane Library, CNKI, Wanfang database and VIP database were systematically searched ...
Honglin Li, Wei Deng, Faqiang Wei, Liangmin Zhang, Fan Chen   +4 more
doaj   +1 more source

Impaired Chaperone‐Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation

Advanced Science, EarlyView.
This graphical abstract illustrates how chaperone‐mediated autophagy (CMA) regulates intervertebral disc degeneration (IDD). Under normal homeostasis (B), CMA degrades cytoplasmic Midnolin (MIDN) to maintain proteostasis. Under inflammatory stress (A), impaired CMA leads to cytoplasmic MIDN accumulation.
Xianglong Chen, Haiyang Gao, Wang Wu, Pengzhi Shi, Yuhang Chen, Anran Zhang, Zhangrong Cheng, Wenbo Wu, Zimu Yu, Yukun Zhang   +9 more
wiley   +1 more source

Comparison of clinical effectiveness between the management of cervical and lumbar disc herniation with percutaneous laser disc decompression followed by interlaminar cervical epidural and lumbar transforaminal epidural steroid injection respectively

Indian Journal of Pain, 2023
Background: Different treatments for discogenic axial back/neck pain or radicular pain to limbs are there from conservative therapies and minimally invasive therapies to open spine surgeries with lots of controversial outcomes.
Shantanu Mallick
doaj   +1 more source