Results 101 to 110 of about 89,243 (282)

Discernment-Oriented Leadership in the Johannine Situation—Abiding in the Truth versus Lesser Alternatives (Chapter in Rethinking the Ethics of John: Implicit Ethics in the Johannine Writings)

, 2012
Excerpt: Leadership within the Johannine situation has been approached from various angles, ranging from structures of leadership, to the location of Johannine Christianity with relation to other groups, to the identity/nonidentity of Johannine leaders.
Anderson, Paul N.
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

CONSIDERATIONS REGARDING THE VALIDITY REQUIREMENTS FOR THE CONSENT [PDF]

Challenges of the Knowledge Society, 2011
For a valid conclusion of a juridical act it is, firstly, necessary for a valid consent to exist. However, the mere existence is not sufficient.
VALENTIN COCEAN
doaj  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The use of empirical data in communal discernment and decision-making processes in the Dutch Reformed Church

Acta Theologica
This article endeavours to present an overview of communal discernment processes developed in the Dutch Reformed Church over the span of two decades. The focus falls on the use of empirical data in these processes.
L. Bosman
doaj   +1 more source

THE DISCERNMENT-REQUIRMENT FOR THE VALIDITY OF CONSENT [PDF]

Challenges of the Knowledge Society, 2017
The provisions of the Civil Code 2009 have not sufficiently clarified the issue of lack of discernment upon conclusion of a juridical act. This study represents an attempt to clarify some of the aspects of this matter, that have been rarely analysed by ...
Valentin COCEAN
doaj  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Perceptions of Forms of Address in European Portuguese in Online Metadiscourse or What Happens When You Use você in Court

Languages
The point of departure for this study is an incident in 2020 when a football manager testifying in a Lisbon court used the pronoun of address você and was reprimanded.
Rita Faria
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source