Results 41 to 50 of about 4,504,709 (295)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Experimental and Numerical Investigations of a Thermal Management System Using Phase-Change Materials and Forced-Air Cooling for High-Power Li-Ion Battery Packs

Batteries, 2023
The thermal management system of a power battery is crucial to the safety of battery operation; however, for the phase-change material (PCM) thermal management system of a battery, the thermal cycling of phase-change material under large discharge rate ...
Yulong Zhang, Shupeng Zhao, Tingbo Zhou, Huizhi Wang, Shen Li, Yongwei Yuan, Zhikai Ma, Jiameng Wei, Xu Zhao   +8 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Simulation study of an inductively coupled plasma discharge with different copper coil designs and gas compositions

AIP Advances, 2019
The physical characteristics for the study of two-dimensional inductively coupled plasma (ICP) discharge with different designs of copper coil and gas composition are presented in this paper.
Fan Lei, Xiaoping Li, Donglin Liu, Yanming Liu, Shun Zhang   +4 more
doaj   +1 more source

Analysis of Low Temperature Preheating Effect Based on Battery Temperature-Rise Model

Energies, 2017
It is difficult to predict the heating time and power consumption associated with the self-heating process of lithium-ion batteries at low temperatures.
Xiaogang Wu, Zhe Chen, Zhiyang Wang
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Temperature‐dependent partial discharge characteristics of high temperature materials at DC voltage for hybrid propulsion systems

High Voltage, 2021
The safe and reliable operation of insulation material used in key high voltage components under extreme environmental conditions represents the major concerns for manufacturers and operators of More Electric Aircrafts (MEA).
Tohid Shahsavarian, Xin Wu, Charles Lents, Di Zhang, Chuanyang Li, Yang Cao   +5 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Emitter discharge variability of subsurface drip irrigation in uniform soils: effect on water-application uniformity [PDF]

, 2008
Emitter discharge of subsurface drip irrigation (SDI) decreases as a result of the overpressure in the soil water at the discharge orifice. In this paper, the variation in dripper discharge in SDI laterals is studied.
Rodríguez Sinobas, Leonor, Juana Sirgado, Luis, Losada Villasante, Alberto, Sánchez Calvo, Raúl, Gil Rodríguez, María   +4 more
core   +1 more source