Results 191 to 200 of about 5,232 (246)

Medicolegal Aspects of Neurosurgery in India: A Narrative Review. [PDF]

Cureus
Sathia Prabhu A, Rakshit P, Patra AP, Vilanilam G, Yadav V.   +4 more
europepmc   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Exploring changes in couples' functioning throughout Parkinson's disease. [PDF]

Br J Health Psychol
Manceau C, Wawrziczny É, Constant É, Flinois B, Dujardin K, Antoine P.   +5 more
europepmc   +1 more source

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

Editorial: Ethical and legal implications of artificial intelligence in public health: balancing innovation and privacy. [PDF]

Front Med (Lausanne)
Ricci G, Bailo P, Gibelli F.
europepmc   +1 more source

Molecular Glue Degraders in Early Development for Cancer Therapy

Medicinal Research Reviews, EarlyView.
ABSTRACT Molecular glue degraders are an emerging class of small molecule allosteric modulators that induce or stabilize protein‐protein interactions, enabling targeted degradation of previously intractable proteins. By redirecting E3 ligases to recognize neosubstrates, proteins that are not typically recognized by a specific E3 ubiquitin ligase, they ...
E. Sila Ozdemir, Hyunbum Jang, Ozlem Keskin, Attila Gursoy, Ruth Nussinov   +4 more
wiley   +1 more source

Beyond DSM Categories: Criteria for Biologically Valid Disease Axes in Psychiatry. [PDF]

J Clin Med
Szarpak L, Rybczynski B, Pruc M, Maj BW, Maslyk M, Niewiadomska I, Cubala WJ.   +6 more
europepmc   +1 more source

Artificial Intelligence Revolution: The Need for a Regulatory and Governance Framework in Dentistry

Journal of Dental Education, EarlyView.
Ehsan Jozaghi
wiley   +1 more source

PVmatAgent: A Large Language Model (LLM) Agent for Perovskite Photovoltaic Material Design and Analysis

Materials Genome Engineering Advances, EarlyView.
PVmatAgent, an LLM‐based autonomous agent integrating 13 domain‐specific tools, executes the complete photovoltaic materials discovery pipeline (from literature retrieval and crystal structure generation to efficiency prediction and commercial assessment), while preventing hallucination via an enforced output parser.
Hangyuan Deng, Yuyan Wu, Youle Wang, Lei Zhang   +3 more
wiley   +1 more source

Closing Editorial: Toward Safe, Equitable, and Intelligent Healthcare. [PDF]

Healthcare (Basel)
Tang D, Lam TYT.
europepmc   +1 more source