Results 91 to 100 of about 81,900 (286)
Bufalin Inhibits the PI3K/AKT Pathway by Targeting GTF3C4 to Impede Breast Cancer Progression
Advanced Science, EarlyView.Mechanisms of Bufalin‐Mediated Intervention in Breast Cancer. ABSTRACT Breast cancer incidence is rising globally, presenting challenges such as treatment side effects and drug resistance. Bufalin is a bufadienolides compound with potential anti‐cancer effects. This study shows that bufalin inhibits malignant proliferation of MDA‐MB‐231 and MCF‐7 cells
Siyu Guo +15 more
wiley +1 more source
Advanced Science, EarlyView.PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li +17 more
wiley +1 more source
Advanced Science, EarlyView.This study identifies Rubicon as a key platelet protein that bidirectionally regulates GPVI and integrin αIIbβ3 signaling. Platelet Rubicon protects against cerebral ischemia‐reperfusion injury by limiting infarction without increasing hemorrhage.
Xiaoyan Chen +11 more
wiley +1 more source
Educação em Revista, 2010 Este artigo tem como tema a supervisão escolar, sendo ela questionada por ângulos diferentes daqueles recorrentemente anunciados nas bibliografias específicas e até então raramente colocados sob suspeita.
Adriana Bergold Leal +1 more
doaj +1 more source
Securities Regulation: Opportunities exist for IIROC to regulate responsively [PDF]
, 2015 This article examines the applicability of responsive regulation within an inter-agency framework in the financial sector. To do so, the article uses the self-regulatory organization that is responsible for governing Canada’s investment dealers and ...
Jakobsen, Kaj Bjarne +3 more
core +3 more sources
Advanced Science, EarlyView.Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge +21 more
wiley +1 more source
Advanced Science, EarlyView.Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu +13 more
wiley +1 more source
TEACHER’S ROLE, DIMENSIONS, STRATEGIES OF ACTING IN TEACHING
Истраживања, 2013 Terms „classroom management“ or „management in class“ often remind us of the changes in behavior of particular students, in typical case by punishing. Perspective of the tunnel in changing operative strategies is not only unnecessary, but it distracts ...
Milica Andevski +2 more
doaj
Prisoner Behavior, Staff Response: Using Prison Discipline Records [PDF]
, 1984 This study is based on official monthly summaries of violations reviewed by the prison discipline committee that were collected over a twenty-month period (September 1978 to May 1980) at the Indiana Reformatory, a maximum security prison for adult male ...
Schafer, N. E.
core
Advanced Science, EarlyView.A programmable passive digital shutter based on multiphase liquid–liquid interface dynamics is introduced for precise fabrication of hydrogel microfibers. By modulating the shutter operation, microfibers with tunable geometry—including linear, helical, tadpole‐like, and spherical forms—are produced.
Dongrui Zhang +14 more
wiley +1 more source