Results 91 to 100 of about 427,190 (308)

Fit to practise? Processes for dealing with misconduct among pharmacists in Australia, Canada, the UK and US [PDF]

open access: yes, 2019
© 2018 Elsevier Inc.In many countries with legal systems based on English common law, pharmacy regulators have a responsibility to protect, promote and maintain the health and safety of patients.
Betty Chaar   +12 more
core   +2 more sources

A Natural Sweetener‐inducible Genetic Switch Controls Therapeutic Protein Expression in Mammals

open access: yesAdvanced Science, EarlyView.
This study develops a natural sweetener, the psicose‐inducible transgene expression (PURE) system based on an Agrobacterium tumefaciens–derived transcriptional repressor PsiR. The PURE system is highly specific to psicose, being insensitive to other sugars and structurally similar molecules.
Longliang Qiao   +16 more
wiley   +1 more source

Gut–Metabolome–Proteome Interactions in Age‐Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi‐Omics Analyses

open access: yesAdvanced Science, EarlyView.
Germ‐free (GF) mice receiving fecal microbiota transplantation (FMT) reveal microbiota‐dependent effects on auditory aging. Integrated metagenomic, metabolomic and proteomic profiling maps gut–inner ear network and highlights 5‐hydroxytryptophan (5‐HTP) as a microbiota‐linked metabolic hub in age‐related hearing loss (ARHL).
Ting Yang   +12 more
wiley   +1 more source

Legal opinion/expert report in the case of Rocio San Miguel Sosa and others v. Venezuela, case nr. 12.923, on request of the Inter-American Court on Human Rights : Expert report in the case of Rocio San Miguel Sosa and others v. Venezuela [PDF]

open access: yes, 2017
First the report examines the preliminary question whether signing a statement or a petition in a political context, such as a petition to carry out a recall referendum on the term of office of a head of state, is to be considered as an act of exercising
Voorhoof, Dirk
core   +1 more source

Intelligent Stain‐Free Histology on Structural Colorimetric Nanocavities

open access: yesAdvanced Science, EarlyView.
Chen and Gan et al. introduce a label‐free imaging platform using inexpensive Nanocavity‐on‐Silicon (NOS) slides. These slides transform subtle tissue variations into vivid structural colors, enabling high‐contrast histological imaging under a regular optical microscope. This stain‐free approach reveals morphological details comparable to traditional H&
Qizhe Chen   +18 more
wiley   +1 more source

Compensating Tendencies in Disciplinary Sanctions: The Case of Hurling

open access: yesJournal of Sports Economics
This paper investigates the presence of compensating tendencies in the awarding of free shots in hurling. Probit models are estimated to examine whether free shots awarded are determined by the score margin, net free count, and net card count at the time.
John Considine   +3 more
openaire   +1 more source

Single‐Cell Profiling Across Immune Tissues and Organs Reveals Immunosenescence Signatures in Male Rhesus Monkeys

open access: yesAdvanced Science, EarlyView.
Single‐cell profiling across bone marrow, spleen, mesenteric lymph, and blood in rhesus monkeys reveals organ Immunosenescence. GZMB rises with age, particularly in cytotoxic and terminally exhausted CD8+ T cells, and BHLHE40 emerges as a key transcription factor enriched across multiple CD8+ subsets, regulating pro‐inflammatory and exhaustion‐related ...
Shengnan Wang   +10 more
wiley   +1 more source

Comparative Study Regarding Combating and Preventing Corruption in Romania and the Republic of Moldova

open access: yesActa Universitatis Danubius: Administratio, 2023
The present paper wants to analyse the level of corruption in Romania and Moldova, the legal framework for civil liability, and the institutions responsible for preventing and combating corruption. Even if the respective countries differ in their form of
Florentina – Iuliana Weber
doaj  

Logic‐Gated HSV‐TK/GCV Suicide Gene Circuit for Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
The BRAS comprises two modular genetic components driven by distinct tumor‐specific promoters and a failsafe layer with the NOT gate. This multi‐input logic gate circuit enables precise, specific expression of HSV‐TK in breast cancer cells with hardly expression in normal cell and effectively inhibits tumor growth in a triple‐negative breast cancer ...
Shasha Tang   +10 more
wiley   +1 more source

Paving the Way to Elucidate Hg's Role in Tumorigenesis

open access: yesAdvanced Science, EarlyView.
Tumorigenesis can result from diverse environmental carcinogens. Among them, mercury—a lifelong bioaccumulative Group 2B carcinogen—has tumorigenic potential that remains poorly understood due to confounding co‐exposures and limited organ‐specific data.
Shouying Li   +10 more
wiley   +1 more source

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