Results 91 to 100 of about 1,727 (258)

An Avalanche Effect Nanomodulator Triggers Cascade Ferroptosis/Cuproptosis for Immunosuppressive Microenvironment Remodeling

open access: yesAdvanced Science, EarlyView.
A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou   +9 more
wiley   +1 more source

LAY JUDGES IN THE DISCIPLINARY CHAMBER OF THE POLISH SUPREME COURT: DISCIPLINARY SANCTIONS TO JUDGES

open access: yesJurisprudencija, 2021
Since 2015, the Republic of Poland has been facing serious challenges to the constitutional order of a democratic state governed by the rule of law, which is based on the principle of the separation of powers and their balance. The highest representative body of the nation – the parliament, elected by universal suffrage – adopted amendments to the law ...
openaire   +1 more source

Iron‐Tannic Acid Hydrogel Mediated Mild Photothermal Therapy Combined With Ferroptosis Enhances Anti‐Tumor Immunity in Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
An injectable gelatin‐based tannic acid–iron hydrogel with mild photothermal therapy could not only induce immunogenic cell death, but also elicit ferroptosis of both tumor cells and tumor‐associated macrophages, resulting in DC maturation, T‐cell infiltration and down‐regulation of ferroptosis‐sensitive M2‐type TAMs levels.
Yuan Zhu   +10 more
wiley   +1 more source

Dual‐Targeting Biomimetic Nanozymes Loaded Microneedle Patch Promotes Scarless Wound Healing Through Anti‐Inflammatory and Anti‐Fibrotic Effects

open access: yesAdvanced Science, EarlyView.
This study developed a dual‐targeting biomimetic nanozyme hybrid system (Cu‐CeO2@ABs‐FTP) and integrated it with HAMA hydrogel to fabricate a microneedle patch (CAF@MN). The patch promotes fibroblast‐mediated wound repair, targets macrophages to induce M2 polarization, and targets myofibroblasts to exert anti‐fibrotic effects, thereby enabling rapid ...
Hongyi Zhang   +14 more
wiley   +1 more source

CONTRIBUTIONS OF GENDER FOR INCLUSIVE EDUCATION IN SCHOOL GEOGRAPHY

open access: yesDidáctica Geográfica, 2015
 In recent years, the teaching of school geography lived a renewal both in terms of curricular requirements and in the knowledge and practices that go round educational institutions.
MARÍA VICTORIA FERNÁNDEZ CASO   +1 more
doaj  

THE PERSONS DEPRIVED OF LIBERTY, AS PASSIVE SUBJECT OF THE CRIMINAL EXECUTION LEGAL RELATIONSHIPS [PDF]

open access: yesChallenges of the Knowledge Society, 2019
The study analyzes the behaviour of individuals deprived of their liberty both as an individual phenomenon and in relations established during the execution of custodial sentences.
Simona Cireșica OPRIȘAN
doaj  

Sunscreen‐Inspired Nano‐Pesticide for UV‐Shielding and Laccase‐Responsive Delivery of Mancozeb With Enhanced Fungicidal Efficacy and Ecological Safety

open access: yesAdvanced Science, EarlyView.
The sunscreen‐inspired nano‐pesticide, MCB@URFSL, provides UV‐shielding, enhanced rainfastness, and laccase‐responsive delivery for improved fungicidal efficacy and high ecological safety. ABSTRACT Fungicides are a crucial tool for protecting crops and ensuring consistent food supply.
Jin Yan   +10 more
wiley   +1 more source

LEGAL ANALYSIS OF DISCIPLINARY SANCTIONS BY TEACHERS TO STUDENTS AT SCHOOL

open access: yesANAYASA : Journal of Legal Studies
Education has a vital role in shaping the character and quality of human resources, with student discipline as one of the key elements in creating a conducive learning environment. This study aims to analyze the law related to the granting of disciplinary sanctions by teachers to students in schools, focusing on the legal challenges faced by teachers ...
Fajar Rachmad Dwi Miarsa   +3 more
openaire   +1 more source

Advancing Clinical Research

open access: yes
Advanced Science, EarlyView.
wiley   +1 more source

Lactate‐Induced K370 Lactylation of STING Inhibits STING‐TBK1 Signaling and Dampens Anti‐Tumor Immunity

open access: yesAdvanced Science, EarlyView.
Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu   +11 more
wiley   +1 more source

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